Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (6): 876-881.

• Articles • Previous Articles     Next Articles

Knoevenagel Condensation Catalyzed by DBU Brönsted Ionic Liquid without Solvent

YING An-guo1,2, LIU Luo1,2, WU Guo-feng1,2, CHEN Xin-zhi1*, YE Wei-dong2*, CHEN Jian-hui2 and ZHANG Kai-yuan2   

  1. 1. Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China;
    2. Xinchang Pharmaceuticals Factory, Zhejiang Medicine Co., Ltd., Xinchang 312500, P. R. China
  • Received:2008-11-12 Revised:2008-12-01 Online:2009-11-25 Published:2010-01-25
  • Contact: CHEN Xin-zhi, E-mail: xzchen@zju.edu.cn; YE Wei-dong, E-mail: yewd@xcpharma.com
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.20776127) and the National Key Technology Research and Development Program of China(No.2007BAI34B07).

Abstract:

A protocol for the Knoevenagel condensation of aromatic aldehydes with methylene compounds catalyzed by task specifed ionic liquid 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium lactate under solvent-free conditions has been developed. The reactions proceed at ambient temperature and the work-up procedures are very simple. Good to excellent yields could be obtained. The ionic liuid could be simply prepared and recycled efficiently.

Key words: Knoevenagel condensation; [DBU][Lac]; Ionic liquid; Aromatic aldehydes; Active methylene compound