Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (6): 856-860.

• Articles • Previous Articles     Next Articles

Design and Synthesis of New Anti-AIDS Drugs——Introducing an Immunomodulator into Delavirdine Derivative

LU Hai-bin1, MI Hao-yu1, CUI Lin-lin2, YU Xiang-Hui1, LIANG Tie3* and WANG En-si1,2*   

  1. 1. College of Life Science,
    2. School of Pharmacy, Jilin University, Changchun 130021, P. R. China;
    3. Affiliated Hospital, Changchun Chinese Medicine University, Changchun 130061, P. R. China
  • Received:2008-11-10 Revised:2009-01-05 Online:2009-11-25 Published:2010-01-25
  • Contact: WANG En-si, E-mail: wangss@jlu.edu.cn; LIANG Tie, E-mail: jlcbslt@vip.sina.com
  • Supported by:

    Supported by Scientific and Technological Development Program Foundation of Jilin Province, China(No.20020503-11).

Abstract:

In consideration of the anti-HIV activities of delavirdine, resveratrol and Pidotimod, a novel kind of   anti-AIDs drug(compounds 5 and 7) was synthesized. Compound 5 was synthesized by linking the delavirdine derivative to pidotimod, compound 7 was synthesized via linking the delavirdine derivative to resveratrol with terephthalic acid as the conjugated compound by two different routes. The structures were confirmed by means of 1H NMR,   13C NMR, IR, MS and elemental analysis. The results for HIV-1 reverse transcriptase assay, quantitative titration of HIV-1 by using MAGI assay and pharmacokinetics assay show that a novel kind of anti-AIDs drug has been synthesized.

Key words: Synthesis; AIDS; Conjugated compound