Synthesis, Crystal Structure and Biological Activities of Novel Di-n-butyl Tin Di-carboxylate

Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (6): 851-855.

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Synthesis, Crystal Structure and Biological Activities of Novel Di-n-butyl Tin Di-carboxylate

WANG Yan-hua, DU Da-feng, ZHU Chao-guang, DU Xi-guang and ZHU Dong-sheng*

Faculty of Chemistry, Northeast Normal University, Changchun 130024, P. R. China

Received:2008-10-22 Revised:2008-12-01 Online:2009-11-25 Published:2010-01-25
Contact: ZHU Dong-sheng. E-mail: zhuds206@nenu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(No.2005038561) and Natural Science Foundation of Province, China(Nos.20060571 and 20070406).

Abstract

Abstract:

A novel macrocyclic complex 2{[(n-Bu₂Sn)₄O₂·L₂]₂·DMF} was synthesized by the reaction of 4-(1,2-dithioethylene)methylene-3,5-disoxo-1,6-heptadiene-1,7-dis-(o-formyl)-dis-p-phenoxyacetic acid(LH₂, compound 1) with di-n-butyltin oxide. Compound 1 and complex 2 were characterized by elemental analysis, FTIR spectroscopy, and ¹H NMR spectroscopy. The crystal structure of complex 2 was determined by single crystal X-ray diffraction analysis. There are two crystallographic independent molecules in complex 2, and each molecule structure is centro-symmetric and features a central rhombus cyclic Bu₄Sn₂O₂ unit with two exocyclic Sn atoms linked at the O atoms of the four-membered ring. In molecule A, the four Sn atoms are five-coordinated. However, in molecule B, the four Sn atoms have two different coordination geometries, the endocyclic Sn atoms are five-coordinated and the exo- cyclic Sn atoms are four-coordinated. The dicarboxylate ligands in molecules A and B bridge exocylic or endocyclic tin atoms, forming two macroheterocycles with 26 atoms. Pilot studies have indicated that complex 2 has good antibacterial and antitumour activities.

Key words: Organotin(IV) carboxylate; Di-n-butyl tin di-carboxylate; Di-n-butyl tin oxide; Crystal structure; Antibacterial activity; Anti-tumour activity

WANG Yan-hua, DU Da-feng, ZHU Chao-guang, DU Xi-guang and ZHU Dong-sheng*. Synthesis, Crystal Structure and Biological Activities of Novel Di-n-butyl Tin Di-carboxylate[J]. Chemical Research in Chinese Universities, 2009, 25(6): 851-855.

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Synthesis, Crystal Structure and Biological Activities of Novel Di-n-butyl Tin Di-carboxylate

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