Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (6): 846-850.

• Articles • Previous Articles     Next Articles

Synthesis and Biological Activities of α-Amino Acylamines Derivatives Containing Furan and Pyridine Ring

XU Yang and XUE Si-jia*   

  1. Department of Chemistry, Shanghai Normal University, Shanghai 200234, P. R. China
  • Received:2008-09-27 Revised:2008-12-01 Online:2009-11-25 Published:2010-01-25
  • Contact: XUE Si-jia. E-mail: forrest313@sohu.com
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.20672073) and Shanghai Leading Academic Discipline Project, China(No.T0402).

Abstract:

In order to find better herbicidal activity and fungicidal activity of α-amino acid derivatives, we introduced furan rings and pyridyl groups to seven different α-amino acids to form a series of 14 novel α-amino acylamines derivatives via dicyclohexylcarbodiimide/4-dimethylaminopyridine(DCC/DMAP) coupling method. The structures of all the compounds prepared were confirmed by IR, LC/MS, 1H NMR, and elemental analysis. The herbicidal and fungicidal results show that some compounds containing glycine and valine substrate have good activities.

Key words: Amino acid; Furan ring; Pyridyl group; Herbicidal and fungicidal activity