Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (6): 807-811.

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Voltammetric Behavior of Degradation Product and Determination of Cefdinir

DONG She-ying1*, YU Zhu-qing1, HAN Xiao-feng1, HUANG Ting-lin2 and ZHENG Jian-bin3   

  1. 1. College of Sciences;
    2. School of Environment and Municipal Engineering, Xi′an University of Architecture and Technology, Xi′an 710055, P. R. China;
    3. Institute of Analytical Science, Shaanxi ProvincialKey Laboratory of Electroanalytical Chemistry, Northwest University, Xi'an 710069, P. R. China
  • Received:2008-12-08 Revised:2009-02-02 Online:2009-11-25 Published:2010-01-25
  • Contact: DONG She-ying. E-mail: dongsyy@126.com
  • Supported by:

    Supported by the Natural Science Foundation of Shaanxi Province in China(No.2005B28).

Abstract:

The electrochemical behavior of the degradation product of cefdinir(CDR) was studied in a 0.05 mol/L NaOH solution by means of linear sweep voltammetry(LSV) and cyclic voltammetry(CV). The results indicate that the C=N bond in the oxime group was reduced. Moreover, a saturated adsorption amount of 1.32×10–10 mol/cm2 at Hg electrode was obtained. The adsorption coefficient β was 1.56×105 L/mol. Gibbs standard energy of adsorption ?G0 at 25 °C was –29.63 kJ/mol and the number of electrons transferred n was 2. A method for the determination of CDR was proposed by differential pulse voltammetry(DPV). The reduction peak currents of the CDR’s degradation product were found to be linear in a concentration range of 4.0×10–7―4.0×10–6 mol/L and that of 4.0×10–8―4.0×10–7 mol/L, respectively. The detection limit was found to be 3.0×10–8 mol/L under the optimized conditions. The applicability of this approach was illustrated by the determination of CDR in capsules. In addition, the mechanism about the degradation of CDR in 0.2 mol/L NaOH was discussed by UV spectrophotometry.

Key words: Cefdinir; Degradation product; Electrode reaction mechanism; Determination