Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (5): 744-747.

• Articles • Previous Articles     Next Articles

A Facile Procedure for Conjugate Addition of Amines to Electron Deficient Alkenes with Metal Oxide as Catalyst

LIANG Xue-zheng1, GAO Shan1 and YANG Jian-guo1,2*   

  1. 1. Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, Shanghai 200062, P. R. China;
    2. Energy Institute, Department of Materials Science and Engineering, Pennsylvania State University, PA 16802, USA
  • Received:2008-07-23 Revised:2008-10-23 Online:2009-09-25 Published:2009-12-07
  • Contact: YANG Jian-guo. E-mail: jgyang@chem.ecnu.edu.cn
  • Supported by:

    Supported by the National Key Project of Scientific and Technical Supporting Programs Funded by Ministry of Science & Technology of China(No.2006BAE03B06).

Abstract:

A novel efficient procedure has been developed for the conjugate addition of amines to electron deficient alkenes. A series of metal oxides was synthesized for catalyzing the conjugate addition of amines and alkenes. After optimizing the reaction conditions, SrO was chosen as the most efficient catalyst for the reactions. The results show that the catalyst is very efficient for the conjugate addition of amines to electron deficient alkenes with the excellent yields in several minutes. Operational simplicity, without need of any solvent, low cost of the catalyst used, high yields, reusability, excellent chemoselectivity and applicability to large-scale reactions are the key features of this methodology.

Key words: Heterogeneous; Conjugate addition; Chemoselective; Metal oxide; Solvent-free