CRCU

Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (5): 686-689.

• Articles • Previous Articles     Next Articles

Regulation of Content of Malondialdehyde by Siqi Decoction via Increasing Activity of Superoxide Dismutase in Blood Serum of Rats with Myocardial Ischemia

SU Yan-bin1,2, JIANG Yi-zhong4, LU Ming1, CHENG Ying-kun1, SU Yan-wen2, ZHANG Fen-rong3 and LI Zheng-qiang1*   

  1. 1. Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, Jilin University, Changchun 130021, P. R. China;
    2. School of Chemical and Pharmaceutical Engineering, Jilin Institute of Chemical Technology, Jilin 132022, P. R. China;
    3. Jilin Provincial Institute for Drug and Food Control, Changchun 130033, P. R. China;
    4. Cardiovascular Surgery Department of China-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China
  • Received:2009-01-08 Revised:2009-03-02 Online:2009-09-25 Published:2009-12-07
  • Contact: LI Zheng-qiang. E-mail: lzq@jlu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos.30570404 and 30670458) and the Natural Science Foundation of Jilin Province, China(No.20050561).

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Abstract:

Effect of Siqi decoction on myocardial ischemia is to prevent cardiac myocyte membrane from damage associated with oxygen free radicals related to NO. To research the regulatoin of the content of malondialdehyde by Siqi decoction, an index of lipid peroxidation, via increasing activity of superoxide dismutase in blood serum of rats with Myocardial Ischemia, the model of myocardium ischemia was made in Wistar rats with posterior pituitary injection through vein in tail. Siqi decoction, Diaoxinxuekang(DK) and Fufangdanshenpian(FD), the latter two drugs of which are effective TCM drugs of anti-myocardial ischemia at present, were administrated to the rats with myocardium ischemia for 5 days to compare the effect of them on myocardium ischemia as reference drugs via measuring the changes of the content of malondialdehyde and the activity of superoxide dismutase in the rat blood serum with myocardial ischemia. There were a remarkable increase in the activity of superoxide dismutase and a decrease in the content of malondialdehyde in the serum of the rats administered Siqi decoction compared with those of the rats in control group, p<0.05. The contents of MDA in the serum of the prevention group rats in the experiments are lower than those of the cure group rats. Anti-Myocardium Ischemia mechanism of Siqi decoction is the regulation of the content of malondialdehyde via increasing activity of superoxide dismutase in the serum of Rats with myocardial ischemia and stimulating the activity of NOS in serum so as to increase NO concentration.

Key words: Siqi decoction; Myocardial ischemia; Posterior pituitary; Malondialdehyde; Superoxide dismutase