Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (5): 644-647.

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Cytotoxic Activity of Some Novel Dicoumarin Derivatives in vitro

ZHANG Hui1, YU Tian-zhi1*, ZHAO Yu-ling2, FAN Duo-wang1, DING Lan3 and ZHANG Shi-dong3   

  1. 1. Key Laboratory of Opto-Electronic Technology and Intelligent Control, Ministry of Education,
    2. School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou 730070, P. R. China;
    3. College of Life Science, Northwest Normal University, Lanzhou 730070, P. R. China
  • Received:2008-09-22 Revised:2008-10-16 Online:2009-09-25 Published:2009-12-07
  • Contact: YU Tian-zhi. E-mail: ytz823@hotmail.com
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.60776006) and the Research Fund of Lanzhou Jiaotong University, China(No.40745).

Abstract:

Some novel dicoumarin derivatives, triethylene-glycol dibenzo[5,6] coumarin-3-carboxylate(1a),PEG (600) dibenzo[5,6]coumarin-3-carboxylate(1b), triethylene-glycol di[7-(N,N'-diethylamino)]-coumarin-3-carboxy-late(2a), were synthesized. The cytotoxic effect of these compounds, along with benzo[5,6]coumarin-3-carboxylic acid(1) and 7-(N,N'-diethylamino)-coumarin-3-carboxylic acid(2), against the SGC-7901 cell lines were determined by Sulforhodamine B(SRB) assay. The preliminary cytotoxicity screening process revealed that the investigated dicoumarin derivatives induced 50% inhibition of the cell viability of SGC-7901 cells at micromolar concentrations. Compound 2a was proved superior to compound 1a according to the IC50 values obtained and the agent with PEG moiety has more contribution to cell-killing ability of the molecules than the remaining agents.

Key words: Triethylene-glycol; PEG; Dicoumarin; SRB; Cytotoxicity test