Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (4): 480-482.

• Articles • Previous Articles     Next Articles

Two Eremophilane-type Sesquiterpenoids from theRhizomes of Ligularia veitchiana(Hemsl.) Greenm

WANG Cai-fang1,2*, ZHAO Yu1, LIU Yan-ze3 and ZHANG Zhen-zhong2   

  1. 1. School of Pharmacy, Zhejiang University, Hangzhou 310058, P. R. China;
    2. School of Pharmacy, Zhengzhou University, Zhengzhou 450051, P. R. China;
    3. Mclean Hospital/Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
  • Received:2008-05-05 Revised:2008-07-11 Online:2009-07-25 Published:2009-10-16
  • Contact: WANG Cai-fang. E-mail: cfwang@zju.edu.cn

Abstract:

Two eremophilane-type sesquiterpenoids from the rhizomes of Ligularia veitchiana(Hemsl.) Greenm were isolated and determined as 10α,11-endoperoxide-1(2)-en-7α-hydroeremophilane(1) and 1(10)-en-2-oxo-7α-isopropanol-eremophilane(2). Compound 1 was a new compound and compound 2 was a new natural product. The structures of the two compounds were established by means of spectral methods including 1H NMR, 13C NMR, 2D NMR and MS.

Key words: Ligularia veitchiana(Hemsl.) Greenm; Eremophilane-type sesquiterpenoids; 10α,11-Endoperoxide-1(2)- en-7α-hydroeremophilane; 1(10)-En-2-oxo-7α-isopropanol-eremophilane