Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (3): 338-342.

• Articles • Previous Articles     Next Articles

Synthesis of 2,4-Diarylcyclooctenopyridines with One-pot Four-component Reactions

WANG Qi-fang and YAN Chao-guo*   

  1. College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, P. R. China
  • Received:2008-04-01 Revised:2008-05-20 Online:2009-05-25 Published:2009-08-07
  • Contact: YAN Chao-guo, E-mail: cgyan@yzu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.20672091) and the Jiangsu Provincial Key Program of Physical Chemistry in Yangzhou University, China.

Abstract:

An efficient one-pot four-component reaction has been developed for the synthesis?of 2,4-diarylcyclooc- tenopyridines, in moderate yields. This route is an effective modified two-step synthesis of Kröhnke pyridine and involves a four-component tandem reaction of pyridinium bromide with aromatic aldehydes and cyclooctanone in a system of NH4OAc/HOAc under microwave irradiation.

Key words: Pyridine; Cycloalkenopyridine; Multicomponent?reaction; Microwave irradiation