Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (3): 312-316.

• Articles • Previous Articles     Next Articles

Novel Efficient Method for Synthesis of N1,4-Disubstituted-1,4-benzodiazepine-2,5-diones

WANG Qiu-yan, YU Jing-jun, LU Cui-fen*, CHEN Zu-xing and YANG Gui-chun   

  1. Key Laboratory for the Synthesis and Application of Organic Functional Molecules of Ministry of Education, School of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, P. R. China
  • Received:2008-11-18 Revised:2008-12-17 Online:2009-05-25 Published:2009-08-07
  • Contact: LU Cui-fen, E-mail: lucf@hubu.edu.cn
  • Supported by:

    Supported by the Natural Science Foundation of Hubei Province, China(No.2007ABA031).

Abstract:

A novel and efficient method was developed for the liquid-phase synthesis of N1,4-disubstituted-benzodiazepine-2,5-diones with 2-chloro-5-nitrobenzoic acid as initiating material via 4 step reactions containing  esterification, “Ulmn reaction”, acylation, alkylation and cyclization. The reaction conditions were mild and the overall yields of the products ranged from 45% to 71%.

Key words: 1,4-Benzodiazepine-2,5-dione; Liquid-phase; Dipeptides