Chemical Research in Chinese Universities ›› 2009, Vol. 25 ›› Issue (3): 291-296.

• Articles • Previous Articles     Next Articles

Interaction Between Mitoxantrone Metal Complex and Titan Yellow by Resonance Rayleigh Scattering Spectra and Its Analytical Application

HU Rong1, YANG Qiong1, ZHANG Shu-ran1 and YANG Ji-dong1,2*   

  1. 1. School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China;
    2. Department of Chemistry and Environment Science, Yangtze Normal University, Chongqing 408100, P. R. China
  • Received:2008-09-11 Revised:2008-11-28 Online:2009-05-25 Published:2009-08-07
  • Contact: YANG Ji-dong, E-mail: flyjd6400@sina.com
  • Supported by:

    Supported by Education Committee of Chongqing City, China(No.KJ081306).

Abstract:

In a pH 2.4 Britton-Robinson buffer medium, the anthracycline antibiotics mitoxantrone(MXT) could react with metal ions such as Pd(II), Co(II) and Cu(II) to form 1:2(molar ratio) cationic chelates, which further reacted with the anionic dye titan yellow to form 1:2 ternary ion-association complexes by electrostatic interaction. As a result, the intensity of resonance Rayleigh scattering(RRS) was enhanced greatly. These RRS spectral characteristics of various metal ion systems were similar, and the maximum RRS wavelengths were all located at 454 nm. But the increments of RRS intensities were different in the series of Pd(II)>Co(II)>Cu(II). The enhanced RRS intensities were proportional to the concentration of MXT in a range of 0.03―2.4 μg/mL and the detection limit(3σ) was 0.009 μg/mL for the Pd(II) system. In this study, the optimum conditions of the reactions and the effects of foreign substances were investigated, in addition, the composition and reaction mechanism of ion-association complexes were discussed. Thus a highly sensitive, simple and rapid method is proposed for the determination of MXT in urine and serum samples.

Key words: Resonance Rayleigh scattering; Mitoxantrone; Metal ion; Titan yellow