CRCU

Chemical Research in Chinese Universities ›› 2006, Vol. 22 ›› Issue (6): 772-775.doi:

• Articles • Previous Articles     Next Articles

Apoptotic Effects of Hypocrellin A on HeLa Cells

FEI Xiao-fang1,2, CHEN Jie1, ZHENG Ke-yan3, WU Wei1, SUN Su-juan4, WANG Li5, MA Lan6, LI Cong7 and TENG Li-rong1   

    1. College of Life Sciences, Jilin University, Changchun 130012, P. R. China;
    2. Key Laboratory of Excited State Physics Process, Chinese Academy of Sciences, Changchun 130022, P. R. China;
    3. Department of Chemistry, Jilin University, Changchun 130012, P. R. China;
    4. Changchun Terumo Medical Products Co., Ltd., Changchun 130000, P. R. China;
    5. Jilin Province Xidian Pharmaceutical Scitech Development Co., Ltd., Changchun 130000, P. R. China;
    6. Department of Biology, Yunnan University, Kunming 650091, P. R. China;
    7. Department of Chemistry, Yunnan University, Kunming 650091, P. R. China
  • Received:2005-09-07 Revised:1900-01-01 Online:2006-11-25 Published:2006-11-25
  • Contact: TENG Li-rong E-mail:tenglr@jlu.edu.cn

Cited

28

Abstract: Hypocrellin A(HA), a photosensitive perylenequinone compound of Hypocrella bambusae, inhibited the proliferation of several tumor cell lines. Human cervical cancer cells, HeLa cells, were used as a model to elucidate the molecular mechanisms of HA-induced tumor cell death. The results show that HA can induce the oligonucleosomal fragmentation of DNA in HeLa cells and also can increase the expression of apoptosis inducer Bax mRNA and that it decreases the expression of apoptosis suppressor, Bcl-2 mRNA, in mitochondria. It can be concluded from the data that HA-induced apoptosis is related to the balance between Bcl-2 and Bax gene expressions.

Key words: Hypocrellin A, Hypocrella bambusae, HeLa cells, Apoptotic effect, Hypocrellin A, Hypocrella bambusae, HeLa cells, Apoptotic effect