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Chemical Research in Chinese Universities ›› 2006, Vol. 22 ›› Issue (3): 343-346.

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Analysis of Norditerpenoid Alkaloids Extracted from Aconitum sinomantanum Nakai by Electrospray Ionization Tandem Mass Spectrometry

XU Qing-xuan, YUE Hao, LIU Zhi-qiang, WANG Yong, YAN Cun-yu, LIU Shu-ying   

  1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China
  • Received:2005-05-10 Online:2006-06-24 Published:2011-08-06
  • Supported by:

    Supported by the State Great Basic Research Project of China(No. 2003CCA03100), the National Natural Science Foundation of China(No. 30472134) and the Great Research Project of Chinese Academy of Sciences(KGCX2-SW-213-06).

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Abstract: Electrospray ionization mass spectrometry(ESI-MS) was applied simultaneously in determining norditerpenoid alkaloids from the roots of Aconitum sinomantanum Nakai (RAS) based on molecular mass information. The tandem mass spectra(ESI-MSn) provided the alkaloidal structural information, through which the existence of these alkaloids was further confirmed. Accordingly, six known norditerpenoid alkaloids were simultaneously determined on the basis of their ESI-MSn spectra. Furthermore, based on the diagnostic fragmentation pathways of alkaloidal MSn, a rapid method for direct detection and characterization of alkaloids from an ethanolic extract of RAS was described.

Key words: Electrospray ionization tandem mass spectrometry (ESI-MSn), Norditerpenoid alkaloid, Aconitum sinomantanum Nakai