CRCU

Chemical Research in Chinese Universities ›› 2006, Vol. 22 ›› Issue (3): 312-314.

• Articles • Previous Articles     Next Articles

Activation Effect of Cathartic Natural Compound Rhein to CFTR Chloride Channel

SHI Lin-lin1,3, XU Li-na1, HOU Shu-guang2, LIN Sen2, YANG Hong2, MA Tong-hui1   

  1. 1. Membrane Channel Research Laboratory, Northeast Normal University, Changchun 130024, P. R. China;

    2. Faculty of Life Sciences, Liaoning Normal University, Dalian 116029, P. R. China;

    3. China-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China
  • Received:2005-11-07 Online:2006-06-24 Published:2011-08-06
  • Supported by:

    Supported by the National Natural Science Fund for Distinguished Young Scholars(No. 30325011), the National Natural Science Foundation of China(Nos. 30470405 and 30570864), Distinguished Young Scholars Fund of Jilin Province(No. 20030112),and Excellent Young Teachers Program of MOE, China.

PDF (PC)

Cited

5

Abstract: The cystic fibrosis transmembrane conductance regulator (CFTR) is a cAMP-activated chloride channel expressed in intestinal exocrine glands, which plays a key role in intestinal fluid secretion. A natural anthraquinone activator of CFTR Cl- channel, rhein, was identified by screening 217 single compounds from Chinese herbs via a cellbased halide-sensitive fluorescent assay. Rhein activates CFTR Cl- transportation in a dose-dependent manner in the presence of cAMP with a physiological concentration. This study provides a novel molecular pharmacological mechanism for the laxative drugs in Traditional Chinese Medicine such as aloe, cascara and senna.

Key words: CFTR chloride channel, Anthraquinone, Laxative drug