CRCU

Chemical Research in Chinese Universities ›› 2006, Vol. 22 ›› Issue (2): 139-144.

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Effect of Notoginsenoside-Rg1 on the Expression of Several Proteins in the Striatum of Rat Models with Parkinson's Disease

ZHANG Lin-bo1,2, LIU Xiao-hua2, JIANG Yuan2, GUO Ping2, SHA Li-jin2, LI Yu1   

  1. 1. Institute of Mycology, Jilin Agricultural University, Changchun 130118, P.R.China;

    2. College of Biotechnology, Jilin Agricultural University, Changchun 130118, P.R.China
  • Received:2005-12-31 Online:2006-04-24 Published:2011-08-06
  • Supported by:

    Supported by the Natural Science Foundation of Jilin Province(No.20030224-2) and the Doctor Priming Foundation of Jilin Agricultural University (2004-2006).

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Abstract: After establishing hemi-Parkinsonian rat models, the relationships between neuron death and the expression of several proteins, such as c-Fos, GFAP, GDNF, NF-κB and some cytokines were determined.Therapeutics experiments with notoginsenoside-Rg1 were carried out.The research results show that the expressions of GFAP, NF-κB and c-Fos will obviously increase in the lesion side of the striatum and the expression of GDNF will decrease, which implies that the signal transduction pathway may participate in the apoptosis in neurons.The levels of some cytokines such as TNF-α, IL-1β in the striatum of PD rat models increased compared to those of normal rats.The results of the therapeutics experiments show that notoginsenoside-Rg1 may repress the immune inflammation response and regulate the immune function through the neuro-immune molecular network.Therefore, notoginsenoside-Rg1 can be used as an effective drug for anti-oxidation and anti-inflammation, and can be used in the therapy of Parkinson's disease(PD).

Key words: Parkinson's disease, Notoginsenoside-Rg1, Neuro-immune molecular network