CRCU

Chemical Research in Chinese Universities ›› 2005, Vol. 21 ›› Issue (5): 566-568.

• Articles • Previous Articles     Next Articles

Synthesis of TP3 Fragment via One Pot Strategy and Its Immune Regulatory Activity

WANG Li-feng, CHEN Jie, SHAN Hui-jie, LI Wei   

  1. Laboratory of Research on Biological Macromolecules, College of Life Science, Jilin University, Changchun 130021, P. R. China
  • Received:2004-12-10 Online:2005-09-23 Published:2011-08-06

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Abstract: We have modified the previously described one-pot peptide synthesis method. The modified method has been successfully applied to the synthesis of TP3. Furthermore, the immune regulatory activity of TP3 has been characterized. The results show that the modified one-pot method can be used to synthesize the biological active peptide with the advantages of low cost and high productivity. Moreover, TP3 has a higher immune regulatory activity than TP5.

Key words: TP3, One-pot synthesis strategy, Activity assay, Immune regulatory activity