CRCU

Chemical Research in Chinese Universities ›› 2004, Vol. 20 ›› Issue (3): 328-333.

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Effect of 2-Selenium Bridged β-Cyclodextrin, Glutathione Peroxidase Mimic on Stroke of Stroke-prone Spontaneously Hypertensive Rats

JIA Zhi-dan1, SUN Ye1, MU Ying1, MA Ji-sheng1,2, YAN Gang-lin1, LUO Gui-min1   

  1. 1. Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University, Changchun 130023, P. R. China;
    2. Jilin Institute of Natural Medicine, Changchun 130012, P. R. China
  • Received:2003-11-19 Online:2004-06-24 Published:2011-08-06
  • Supported by:

    Supported by the Foundation of Ministry of Science and Technology of China(No.2001AA215315 of "863" project and No.G2000078102 of "973" project), the National Natural Science Foundation of China(No.20272016 and 30200050) and the Financial Support of Jilin University.

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Abstract: To investigate the treatment effect of 2-selenium bridged β-cyclodextrin(2-SeCD), a GPX mimic, on the stroke of stroke-prone spontaneously hypertensive rats(SHRSP), fifty-two SHRSP of 8-week old were randomly divided into four groups A, B, C and control group D. The rats of groups A, B, C and D were given 1.0%-1.5% NaCl mass fraction as drinking fluid. After onset of stroke, groups A, B and C were given orally 16.05, 160.5 and 1605 mg·kg-1·day-1 of 2-SeCD, respectively, and group D was given water for 2 weeks. The clinical score of stroke, systolic blood pressure(SBP), survival time of rats were recorded and the histopathologic examinations of their brain and carotid artery were made after decapitation. The clinical scores of stroke after treatment with 160.5 mg·kg-1·day-1(Group B) and 1605 mg·kg-1·day-1(Group C) of 2-SeCD are 2.55±0.98 and 1.98±0.79, respectively, those are obviously lower than that of group D(3.41±0.83, p<0.01). The survival days in group B(10.0±8.6) and group C(14.4±7.9) are longer than that for group D(4.7±2.9, p<0.01). The electron microscope study showed that the endothelium of carotid artery was near to normal in group B and group C, while it was seriously injured in control group D and mildly injured in group A. 2-SeCD may effectively be used to treat the stroke for SHRSP.

Key words: 2-Selenium bridged β-cyclodextrin, Glutathione peroxidase, Enzyme mimic, Stroke, Stroke-prone Spontaneously hypertensive rat