CRCU

Chemical Research in Chinese Universities ›› 2001, Vol. 17 ›› Issue (S1): 176-177.

• Articles • Previous Articles     Next Articles

Design,Synthesis,Anticancer Pharmacology of Actinomycin D Analogues:5,5'-MeSer2-ActD and 5,5,-MeAla2-ActD

NI Jing-Man1, YANG Xiao-Wu2, JIA Zheng-Ping2, PAN Xing-Fu3, WANG Rui2   

  1. 1. Department of Pharmacy, Lanzhou Medical College, Lanzhou 730000;
    2. Department of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000;
    3. Department of Chemistry. College of Chemistry and Chemical Engineering Lanzhou University, Lanzhou 730000
  • Online:2001-12-31 Published:2016-03-14
  • Supported by:

    This work was supported by the Natural Science Foundation of Gansu Province(ZS001-A23-057-Y)

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Abstract:

Actinomycin D(ActD,Figure 1.),containing a planar phenoxazonc ring and two cyclic pentapeptides,is one of the most intensely studied anticancer drugs and currently used to treat highly malignant tumors,such as Wilms' tumor and gestational choriocarcinoma.Although ActD possesses high antitumor activities,its clinical usefulness is limited by its extreme cytotoxicity.