Chemical Research in Chinese Universities ›› 2001, Vol. 17 ›› Issue (S1): 119-119.

• Articles • Previous Articles     Next Articles

Enantioselective Synthesis of Protease Inhibitors and Anti-HIV Agents

WANG Zhe   

  1. DuPont Pharmaceuticals Company, Research & Development, Chambers Works, Deepwater, NJ 08023
  • Online:2001-12-31 Published:2016-03-14

Abstract:

A highly enantio- and diastereoselective Ireland-Claisen rearrangement of chiral C3-(acyloxy)-vinyl silanes for the synthesis of anti-disubstituted succinic acid,an important intermediate for matrix metalloprolease inhibitors,has been developed(enantio- and anti/syn selectivities up to 95% and 38/1).