CRCU

Chemical Research in Chinese Universities ›› 2001, Vol. 17 ›› Issue (S1): 111-111.

• Articles • Previous Articles     Next Articles

Unique Cyclin-Dependent Kinase(CDK) Inhibitors at the ATP-site

LI Lin, CHONG Wesley K M., DUVADIE Rohit K, CHU Shao Song, YANG Y. Michelle, NONOMIYA Jim, TUCKER Kadthleen D., KNIGHTON Daniel R., FERRE RoseAnn, LUNDGREN Karen, ESCOBAR Jorge, MINNICK Sharon price, HUBER Andrea, KOUDRIAKOVA T atiana, ARRUDA Jeannie, SISSON Wes, AUST Robert M., VERKHIVKER Gennady M., SCHAFFER Lana, ROSE Peter w, and LEWIS Cristina T.   

  • Online:2001-12-31 Published:2016-03-14

PDF (PC)

Abstract:

Control of the cell cycle could be applicable in new approaches for cancer chemotherapy.The cyclin-dependent kinases(CDK's) and their corresponding complexes with cyclins are regulatory enzymes for which we have discovered a novel small molecule series of inhibitors,with potencies in the nanomolar range and good selectivity for the CDK's versus other kinases.