Chemical Research in Chinese Universities ›› 1997, Vol. 13 ›› Issue (4): 336-343.
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FU Yan-jun, ZHUO Ren-xi
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Supported by the Foundation of the State Education Commission of China.
Abstract: DTPA was covalently conjugated to the copolymer of L-lysine and L-tyrosine, then transchelated with Gd-EDTA,the resultant polymer chelates were further reacted with 6-O-bromoacety-l-D-galactose or methyl lactobionyloxyacetate to give PLT(Gd-DTPA) with galactose moiety as liver- targeting group.These macromolecular MRI contrast agents were characterized by means of FT-IR, ICP-AES, elementary analyses and UV-Vis spectrophotometry. Their in vitro relaxivity and liver targeting property in mice were also investigated.
Key words: MRI macromolecular contrast media(MMCM), Polylysine, Hepatocyte-targeting, Relaxivity, Biodistribution
FU Yan-jun, ZHUO Ren-xi . Studies on Hepatocyte-Targeting Magnetic Resonance Imaging Macromolecular Contrast Media[J]. Chemical Research in Chinese Universities, 1997, 13(4): 336-343.
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https://crcu.jlu.edu.cn/EN/Y1997/V13/I4/336
