CRCU

Chemical Research in Chinese Universities ›› 1997, Vol. 13 ›› Issue (3): 201-206.

• Articles • Previous Articles     Next Articles

Studies on the Binding of Tris(1,10-phenanthroline)Nickel(Ⅱ) to Calf Thymus DNA

JIN Lan1, YANG Pin1, LI Qing-shan1, YANG Bin-sheng2   

  1. 1. State Key Laboratory of Coordination Chemistry, Nanjing University, Nnjing 210093;
    2. Institute of Molecular Science, Shanxi University, Taiyuan 030006
  • Received:1995-04-25 Online:1997-08-24 Published:2011-08-17
  • Supported by:

    Supported by the National Natural Science Foundation of China and Natural Science Foundation of Shanxi Province.

PDF (PC)

Cited

17

Abstract: Absorbance and fluorescence methods were used to study the interaction of - and A-tris (phenanthroline) nickel ( Ⅱ) complex with calf thymus DNA. It was con- cluded that Δ-Ni(phen)32+ preferentially bound to DNA. Especially the fluorescence Scatchard plots were discussed for the binding of EthBr to calf thymus DNA in the presence of varying concentrations of the metal complex. Theses studies indicated that both the isomers bound to DNA by two acting types, namely, intercalative and electrostatic bound modes.

Key words: Chiral metal complexe, DNA, Binding mode