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Chemical Research in Chinese Universities ›› 1994, Vol. 10 ›› Issue (2): 93-101.

• Articles • Previous Articles     Next Articles

A Facile Synthesis of Indolizines by 1,3-Dipolar Cycloaddition of Pyridinium and Related Heteroaromatic Ylides with Alkenes in the Presence of TPCD, Py4Co(HCrO4)2

ZHU Chang-cheng, WEI Xu-dong, HU Jia-xin, WANG De-fen, HU Hong-wen   

  1. Department of Chemistry, Nanjing University, Nanjing, 210008
  • Received:1993-10-10 Online:1994-04-24 Published:2011-08-17

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Abstract: A facile one-step method is presented for the synthesis of indolizines in moder-ate to high yields by reaction of pyridinium, quinolinium and isoquinolinium ylideswith acrylonitrile, methyl acrylate and diethyl maleate respectively in the presenceof tetrakis-pyridino-cobalt(Ⅱ)dichromate (TPCD) in DMF.

Key words: Indolizines, 1,3-Dipolar cycloaddition, Pyridinium Ylides, Quinolini-um ylides, Isoquinolinium ylides