Multifunctional Liquid Metal Active Material for Wound Repair and Motion Monitoring via Free Radical Polymerization Assembly

doi:10.1007/s40242-024-4195-1

Chemical Research in Chinese Universities ›› 2024, Vol. 40 ›› Issue (6): 1011-1022.doi: 10.1007/s40242-024-4195-1

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Multifunctional Liquid Metal Active Material for Wound Repair and Motion Monitoring via Free Radical Polymerization Assembly

WEI Zheng^1,2, WAN Sikang^3,4, JIA Bo¹, CHENG Wenhao^1,2, LI Ming^1,2, CHEN Jing¹, LIU Yawei¹, ZHANG Hongjie^1,2,3,4, LIU Kai^1,2,3,4, WANG Fan^1,2

1. State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China;
2. School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei 230026, P. R. China;
3. Engineering Research Center of Advanced Rare Earth Materials of the Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China;
4. Xiangfu Laboratory, Jiaxing 314102, P. R. China

Received:2024-09-21 Online:2024-12-01 Published:2024-10-26
Contact: WAN Sikang,skwan@tsinghua.edu.cn;LIU Kai,kailiu@tsinghua.edu.cn;WANG Fan,wangfan@ciac.ac.cn E-mail:skwan@tsinghua.edu.cn;kailiu@tsinghua.edu.cn;wangfan@ciac.ac.cn
Supported by:
This work was supported by the National Natural Science Foundation of China (Nos. 52222214, 52372274, 22388101, 22020102003, 22125701), the National Key Research and Development Program of China (No. 2020YFA0908900), the Natural Science Foundation of Jilin Province, China (Nos. 20240101175JC, 20210101366JC), the Young Elite Scientists Sponsorship Program by the China Association for Science and Technology (No. 2022QNRC001), the Beijing Natural Science Foundation, China (No. 2244071), the Xiangfu Lab Research Project, China (No. XF012022C0200) and the Funding from China Postdoctoral Science Foundation (No. 2022M721802).

Abstract

Abstract: Bacterial infections and excessive oxidative stress seriously hinder the healing of skin wounds. Traditional wound dressings can only serve as physical barriers and lack active molecules essential for actively promoting wound healing. Herein, an antibacterial and antioxidant liquid metal inorganic active material is developed for wound repair through in situ polymerization of chitosan/acrylic acid precursor solution initiated by tannic acid-coated liquid metal nanoparticles, without extra initiators and ultraviolet (UV) light. The tannic acid component enables the inorganic active material to exhibit antioxidant property, which can remove 90% of free radicals and relieve cellular oxidative stress. The chitosan component endows the inorganic active material with antibacterial property, effectively inhibiting the growth of Staphylococcus aureus and Escherichia coli (killing ratio: 90%). In vivo experiment demonstrates that this inorganic active material can promote the healing of Staphylococcus aureus-infected wound, achieving a closure rate of 98.16% on the 9th day. Meanwhile, this inorganic active material exhibits good electrical conductivity, enabling timely and stable monitoring of human joint movements. This work offers a simple strategy for developing multifunctional inorganic active material, which holds great potential for wound repair and motion monitoring.

Key words: Liquid metal, Free radical polymerization, Inorganic active material, Wound repair, Motion monitoring

WEI Zheng, WAN Sikang, JIA Bo, CHENG Wenhao, LI Ming, CHEN Jing, LIU Yawei, ZHANG Hongjie, LIU Kai, WANG Fan. Multifunctional Liquid Metal Active Material for Wound Repair and Motion Monitoring via Free Radical Polymerization Assembly[J]. Chemical Research in Chinese Universities, 2024, 40(6): 1011-1022.

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Multifunctional Liquid Metal Active Material for Wound Repair and Motion Monitoring via Free Radical Polymerization Assembly

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