Afterglow Nanoprobes for In-vitro Background-free Biomarker Analysis

doi:10.1007/s40242-024-3280-9

Abstract

Abstract: Accurate detection of biomarkers is essential for disease diagnosis. Although the highly sensitive fluorescence probes are feasible for the above goal, it is typically interfered by the auto-fluorescence and light scattering of the biological samples. Photochemical afterglow system (consisting of photosensitizer, afterglow substrate and emitter) based on cascade photochemical reactions exhibits long-lived luminescence (seconds to hours), thus avoiding background interference. With the assistance of polymers, such as polystyrene microspheres, the photochemical afterglow systems have been transformed into homogeneous and water-soluble nanoparticles, and used for in-vitro biomarker analysis. Here, we summarized the principle, preparation and applications of these afterglow nanoparticles, and evaluated their performance in clinical sample testing by comparing with other nanoparticle-based methods. Finally, several problems and possible solutions of afterglow nanoparticle-based methods in biomarker determination were also mentioned.

Key words: Photochemical afterglow, In-vitro analysis, Background-free detection, Biomarker

ZHENG Ting, WANG Ying, LI Xianming, LI Chenghui, WU Peng. Afterglow Nanoprobes for In-vitro Background-free Biomarker Analysis[J]. Chemical Research in Chinese Universities, 2024, 40(2): 213-224.

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