Abstract: The vast majority of reported MOFs are composed of two building blocks:one metal ion and one organic linker. In such MOFs, the metal-linker motifs repeat periodically throughout the crystal such that composition and structure (and properties/functions) are uniform in all directions. Thus, such MOFs are isotropic materials. The introduction of multiple chemical components into a MOF can significantly increase structural and compositional complexity and lead to directional variance of composition, anisotropy, within an ordered molecular scaffold. The origins and emergence of this ‘complexity within order’ and anisotropy are detailed by Li and coworkers in a recent Nature Reviews Materials article entitled ‘Anisotropic Reticular Chemistry’^[1].