A Smartphone-assisted Paper-based Analytical Device for Fluorescence Assay of Hg2+

doi:10.1007/s40242-019-9234-y

Chemical Research in Chinese Universities ›› 2019, Vol. 35 ›› Issue (6): 972-977.doi: 10.1007/s40242-019-9234-y

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A Smartphone-assisted Paper-based Analytical Device for Fluorescence Assay of Hg²⁺

YE Jiawen^1,2,3, GENG Yijia¹, CAO Fanghao^1,3, SUN Dan¹, XU Shuping¹, CHANG Jingjing², XU Weiqing¹, CHEN Qidan³

1. State Key Laboratory of Supramolecular Structure and Materials, Institute of Theoretical Chemistry, Jilin University, Changchun 130012, P. R. China;
2. School of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022, P. R. China;
3. School of Chemical Engineering and New Energy Materials, Zhuhai College, Jilin University, Zhuhai 519041, P. R. China

Received:2019-08-29 Revised:2019-10-20 Online:2019-12-01 Published:2019-11-29
Contact: XU Weiqing, CHEN Qidan E-mail:wqxu@jlu.edu.cn;qidanchen@jlu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21873039, 21573087, 21573092), the Basic and Applied Basic Research Foundation of Guangdong Province, China(No.2019A1515010596), the "Three Levels" of Talent Project of Zhuhai College, Jilin University, China(No.2018TL006) and the Science and Technology Innovation Team Project of Zhuhai College, Jilin University, China(No.2018CXKYTD005).

Abstract

Abstract: Rapid, efficiency and portable detection systems in low-resource settings with limited laboratory equipment and technical expertise are urgently needed. Herein, an integrated platform composed of a paper-based analytical device and a smartphone detection system for Hg²⁺ onsite testing was developed. Nitrogen-doped carbon dots(N-CDs) were synthesized by a simple hydrothermal method using citric acid as the carbon source and ethanediamine as the nitrogen source, which gave out bright blue fluorescence under the excitation at 350 nm UV light and the absolute fluorescence quantum yield was 17.1%. The fluorescence of the prepared N-CDs can be effectively quenched by Hg²⁺. In addition, an external attachment of smartphone for illumination and external light interference was designed to trace the fluorescence signals, and a software application of Android system with simple operation program was developed to perform snapshot and image processing. The smartphone-assisted detection system was combined with the N-CDs decorated paper chip to achieve the sensitive detection of Hg²⁺ in water samples. This integrated method for reliable sensing of Hg²⁺ shows a good linear detection range of 10-800 μmol/L(R²=0.9595) with detection limit of 1.07×10^-8 mol/L.

Key words: Paper-based analytical device, Nitrogen-doped carbon dot, Integrated sensing platform, Mercury ion

YE Jiawen, GENG Yijia, CAO Fanghao, SUN Dan, XU Shuping, CHANG Jingjing, XU Weiqing, CHEN Qidan. A Smartphone-assisted Paper-based Analytical Device for Fluorescence Assay of Hg²⁺[J]. Chemical Research in Chinese Universities, 2019, 35(6): 972-977.

References

[1] Shahvar A., Saraji M., Shamsaei D., Sens. Actuators B Chem., 2018, 5, 891
[2] Yang K., Peretz-Soroka H., Liu Y., Lin F., Lab Chip, 2016, 16, 943
[3] Zhang D., Liu Q., Biosens. Bioelectron., 2016, 75, 273
[4] Sumriddetchkajorn S., Chaitavon K., Intaravanne Y., Sens. Actuators B Chem., 2014, 191, 561
[5] Chen Y., Fu Q., Li D., Xie J., Ke D., Song Q., Tang Y., Wang H., Anal. Bioanal. Chem., 2017, 409, 6567
[6] Liu Z., Zhang Y., Xu S., Zhang H., Tan Y., Ma C., Song R., Jiang L., Yi C., Anal. Chim. Acta, 2017, 966, 81
[7] Gong M., Sinton D., Chem. Rev., 2017, 117, 8447
[8] Liu C., Gomez F. A., Miao Y., Cui P., Lee W., Talanta, 2019, 194, 171
[9] Fang M., Zhou L., Zhang H., Liu L., Gong Z., Food Chem., 2019, 274, 156
[10] Xu Y., Liu J., Zhang J., Zong X., Jia X., Li D., Wang E., Nanoscale, 2015, 7, 9421
[11] Qu H., Zhang Y., Qu B., Kong H., Qin G., Liu S., Cheng J., Wang Q., Zhao Y., Biosens. Bioelectron., 2016, 81, 358
[12] Di Nardo F., Anfossi L., Giovannoli C., Goftman V., Goryacheva I. Y., Baggiani C., Talanta, 2016, 150, 463
[13] You M., Lin M., Gong Y., Wang S., Li A., Ji L., Zhao H., Ling K., Wen T., Huang Y., Gao D., Q Ma., Wang T., Ma A., Li X., Xu F., ACS Nano, 2017, 6, 6261
[14] Mohammad J. M., Talanta, 2019, 196, 456
[15] Asadian E., Ghalkhani M., Shahrokhian S., Sens. Actuators B Chem., 2019, 293, 183
[16] Li L., Yu B., You T., Biosens. Bioelectron., 2015, 74, 263
[17] Luo L., Wang P., Wang Y., Wang F., Sens. Actuators B:Chem., 2018, 273, 1640
[18] Yan F., Kong D., Luo Y., Ye Q., Wang Y., Chen L., Mater. Sci. Eng. C Mater. Biol. Appl., 2016, 68, 732
[19] Kaur N., Sharma V., Tiwari P., Actuators B:Chem., 2019, 291, 275
[20] Zhu S., Zhao X., Song Y., Lu S., Yang B., Nano Today, 2016, 11, 128
[21] Zhou N., Zhang X., Shi Y., Li Z., Feng Z., New J. Chem., 2018, 42, 14332
[22] Lan M., Zhang J., Chui Y., Wang H., Yang Q., Zhu X., Wei H., Liu W., Ge J., Wang P., Chen X., Lee C., Zhang W., J. Mater. Chem. B, 2015, 3, 127
[23] Chen T., Wang X., Liu Y., Li B., Cheng Z., Wang Z., Lai W., Liu X., Phys. Chem. Chem. Phys., 2017, 19, 5504
[24] Hallaj R., Hosseonchi Z., Babamiri B., Zandi S., Spectrochim. Acta, Part A, 2019, 216, 418
[25] Zhang R., Chen W., Biosens. Bioelectron., 2014, 55, 83
[26] Huang H., Weng Y., Zheng L., Yao B., Weng W., Lin X., J. Colloid. Interf. Sci., 2017, 506, 373
[27] Li M., Wang B., An X., Li Z., Zhu H., Mao B., Calatayud D., James T., Dyes and Pigments, 2019, 170, 107476
[28] Qiu Y., Dong L., Xiang D., Li L., Zhu L., Chem. Res. Chinese Universities, 2018, 34(6), 971
[29] Tanvir F., Yaqub A., Tanvir S., An R., Anderson W., Materials, 2019, 12, 1533
[30] Qi Y., Zhao J., Weng G., Li J., Li X, Zhu J., Zhao J., J.Mater. Chem. C, 2018, 6, 12283

A Smartphone-assisted Paper-based Analytical Device for Fluorescence Assay of Hg²⁺

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