Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor

doi:10.1007/s40242-017-7112-z

Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (5): 773-778.doi: 10.1007/s40242-017-7112-z

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Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor

SHEN Xizhou¹, HE Huajun^1,4, YANG Bowen², ZHAO Zhigang², SHAO Kaiyuan³, HU Wenxiang^1,3

1. School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan 430070, P. R. China;
2. College of Chemistry and Environment Protection Engineering, Southwest University for Nationalities, Chengdu 610041, P. R. China;
3. Jingdong Xianghu Laboratory of Beijing Excalibur Space, Military Academy of Medical Sciences, Beijing 101601, P. R. China;
4. Food and Drugs Inspection & Testing Center of Jingning County, Jingning 323500, P. R. China

Received:2017-03-27 Revised:2017-05-16 Online:2017-10-01 Published:2017-07-03
Contact: HU Wenxiang,E-mail:huwx66@163.com E-mail:huwx66@163.com
Supported by:
Supported by the Beijing Municipal Special Fund Project, China(No.009-0753003); the National Science and Technology Innovation Fund Project of China(No.09C26211100074).

Abstract

Abstract:

In this paper, the activities of electrophilic sites on benzene ring of 4-substituted anilines and their acyl compounds were studied with the quantitative indicator of multiphilicity descriptor. Four substituents were synthesized with microwave irradiation in good yields to verify the quantitative analysis data. Friedel-Crafts acylation was carried out by the microwave method for the first time.

Key words: Quantum chemical calculation, Electrophilic site, Multiphilicity descriptor, Benzodiazepine, Electrophilic substitution reaction

SHEN Xizhou, HE Huajun, YANG Bowen, ZHAO Zhigang, SHAO Kaiyuan, HU Wenxiang. Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor[J]. Chemical Research in Chinese Universities, 2017, 33(5): 773-778.

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Studies on the Activities of Electrophilic Sites on Benzene Ring of 4-Substituted Anilines and Their Acyl Compounds with Multiphilicity Descriptor

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