Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester

doi:10.1007/s40242-017-7103-0

Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (4): 569-573.doi: 10.1007/s40242-017-7103-0

• Articles • Previous Articles Next Articles

Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester

WANG Bowei¹, HOU Wanshi², WANG Yingnan², LI Shaoheng², LIU Zhihui³, SONG Zhiguang²

1. The Second Hospital, Jilin University, Changchun 130022, P. R. China;
2. Department of Organic Chemistry, College of Chemistry, Jilin University, Changchun 130021, P. R. China;
3. Department of Prosthodontics, Stomatology Hospital of Jilin University, Changchun 130021, P. R. China

Received:2017-03-16 Revised:2017-04-06 Online:2017-08-01 Published:2017-07-19
Contact: Zhiguang E-mail:szg@jlu.edu.cn
Supported by:
Supported by the Development Project of the Pharmaceutical Industry of Jilin Province，China（Nos.20140311088YY，20150311070YY，20170307024YY），the Significant Science and Technology Project of Changchun City，China（No.2015054），the Key Science and Technology Project of Jilin Province，China（No.20140204066SF） and the Significant Science and Technology Item of-Double Ten Project‖ of Changchun City，China（No.16SS12）.

Abstract

Abstract:

Ibuprofen(IBU) and its derivatives are widely used in treating many diseases, such as depression, glomerulonephritis, fever caused by common cold or influenza, and rheumatoid arthritis. While in clinical trials, IBU was found to have many side effects. To weaken and prevent these side effects, a derivative called ibupr ofen-1-acetoxyethyl ester was synthesized in this paper. The maximum concentration(c_max) in a shorter time was compared with IBU at the same dose.

Key words: Ibuprofen, Ibuprofen-1-acetoxyethyl ester, Pharmacodynamic research

WANG Bowei, HOU Wanshi, WANG Yingnan, LI Shaoheng, LIU Zhihui, SONG Zhiguang. Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester[J]. Chemical Research in Chinese Universities, 2017, 33(4): 569-573.

References

[1] Zhao Y. M., Xia D., Ai C. P., Xiang G. Y., Chin. J. Med. Chem., 2005, 15(6), 360
[2] Zhu J., Huang F., Chin. J. New Drugs, 2009, 18(6), 497
[3] Zheng T. C., Fine Chem. Inter., 2010, 40(3), 1
[4] Chen S. Y., Hang Q., Ao G. Z., Hou B. B., Xu G. L., Chin. J. Syn. Chem., 2014, 22(6), 781
[5] Sun D., Lyu M., Lyu Z., Li Q., Yi B. X., China Pharmaceuticals, 2016, 25(8), 20
[6] Guo C. B., Chen X. H., Yi X., Guo Z. R., Chu F. M., Cheng G. F., Acta Chimica Sinica, 2005, 63(9), 841
[7] Song N., Li Y. X., Sun X., Qu F., Acta Pharmaceutica Sinica, 2004, 39(2), 105
[8] Zhao X. L., Chen D. W., Formulation and Preparation Method of Eugenol Ibuprofen, CN1597656A, 2005
[9] Liu Y. F., Zhang H., Peng D. M., Liao D. F., Preparation and Its Useway of 9-O-ibuprofen Berberine Ester, CN104817556A, 2015
[10] Fan H. Y., Fu L., Wang S., Synthesis and Applicantion of Phillygenin Ibuprofen Ester, CN 105461731A, 2016
[11] Wang J., Zhang X. R., Li Y., Chen L., Synthesis and Formulation of Ibuprofen Polyethylene Glycol Ester, CN 106008955A, 2016
[12] Abraham N., Ada R., Edward N., Bernard L., Metabolically Stabilized Oxyalkylene Esters and Uses Thereof, WO 9840066A1, 1998
[13] Ma T. H., Modern Medicine Health, 2011, 27(21), 3279
[14] Yuan H. L., Hu J. M., Wei. Y. H., Zhang J. P., Zhou Y., Wu X. A., Chin. J. New Drugs, 2013, 22(3), 351
[15] Song S. F., Luan Y. X., Lu F. S., Chem. Res. Chinese Universities, 2007, 23(6), 749
[16] Zhang L. Z., Ren Z. J., Lu A. M., Zhao Z., Xu W. Q., Bao Q. Q., Ding W. J., Yang C. L., Chem. Res. Chinese Universities, 2015, 31(2), 228
[17] Liu J. M., Xu J. H., Liu Y. Y., Xu X. S., Yuan Q. S., Chem. Res. Chinese Universities, 1998, 19(12), 1965
[18] Sun Y. T., Zhang Y. P., Bi S. Y., Sun Y., Liu H., Zhai Y. J., Zhang H. Q., Chem. J. Chinese Universities, 2009, 30(6), 1095
[19] Sun Y., Wang B., Chem. J. Chinese Universities, 2012, 33(4), 838

Synthesis and Pharmacodynamics of Ibuprofen-1-acetoxyethyl Ester

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 3

Recommended Articles

Metrics

Comments

[1]	TANG Duihai, ZHANG Weiran, WANG Yifan, MIAO Jing, QIAO Zhen'an, HUO Qisheng, ZHANG Lirong. co-Condensation Synthesis of Salicylaldimine Calcium Complex Containing Mesoporous Silica Nanoparticles as Carriers for Drug Release [J]. Chemical Research in Chinese Universities, 2014, 30(4): 531-537.
[2]	JI Jin-gou, ZHANG Jing-fen, HAO Shi-lei, WU Dan-jun, LIU Li, XU Yi. Preparation, Characterization of Hydrophobic Drug in Combine Loaded Chitosan/Cyclodextrin/Trisodium Citrate Nanoparticles and in vitro Release Study [J]. Chemical Research in Chinese Universities, 2012, 28(1): 166-170.
[3]	SONG Shao-fang , LUAN Yu-xia , LU Fu-sui . Activity and Enantioselectivity of Lipase Immobilized in CTAB Microemulsion-based Gels [J]. Chemical Research in Chinese Universities, 2007, 23(6): 749-752.