Therapeutic Drug Monitoring of Vancomycin and Voriconazole by Liquid Chromatography-Tandem Mass Spectrometric Method

doi:10.1007/s40242-017-7051-8

Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (3): 339-342.doi: 10.1007/s40242-017-7051-8

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Therapeutic Drug Monitoring of Vancomycin and Voriconazole by Liquid Chromatography-Tandem Mass Spectrometric Method

LI Yanyan¹, YIN Lei^1,2, LI Yanhua¹, SUN Zhihui¹, ZHAO Xiaojun¹, GAO Mingyue¹, WANG Hongliang¹

1. The First Hospital of Jilin University, Changchun 130021, P. R. China;
2. School of Life Science, Jilin University, Changchun 130012, P. R. China

Received:2017-02-13 Revised:2017-03-31 Online:2017-06-01 Published:2017-04-24
Contact: 10.WANG Hongliang,E-mail:hongliangwangjlu@163.com E-mail:hongliangwangjlu@163.com
Supported by:
Supported by the National Natural Science Foundation of China(Nos.81603182, 81430087, 81673396).

Abstract

Abstract:

A reliable liquid chromatography-tandem mass spectrometric(LC-MS/MS) method was developed and validated for the simultaneous determination of vancomycin and voriconazole in human plasma. The analytes and internal standard 10-hydroxycarbazepine were separated at a flow rate of 0.9 mL/min using a Zorbax SB-C₁₈ column (50 mm×4.6 mm, 2.7 μm). Positive ion electrospray ionization was used to detect vancomycin, voriconazole and intrenal standard(IS) 10-hydroxycarbazepine followed by multiple reaction monitoring(MRM) of the transition at m/z 725.5→144.2, 350.3→281.0 and 253.1→208.0, respectively. The total run time for both vancomycin and voriconazole samples was 5 min; 0.30 μg/mL was the lower limit of quantification. The precision of intraday and interday was no more than 12.4%. The method was successfully and resoundingly applied in therapeutic drug monitoring of 156 patients treated with vancomycin and voriconazole.

Key words: Liquid chromatography-tandem mass spectrometry(LC-MS/MS), Vancomycin, Voriconazole, Therapeutic drug monitoring

LI Yanyan, YIN Lei, LI Yanhua, SUN Zhihui, ZHAO Xiaojun, GAO Mingyue, WANG Hongliang. Therapeutic Drug Monitoring of Vancomycin and Voriconazole by Liquid Chromatography-Tandem Mass Spectrometric Method[J]. Chemical Research in Chinese Universities, 2017, 33(3): 339-342.

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Therapeutic Drug Monitoring of Vancomycin and Voriconazole by Liquid Chromatography-Tandem Mass Spectrometric Method

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