Poly (L-lactide)-grafted Bioglass/Poly (lactide-co-glycolide) Scaffolds with Supercritical CO2 Foaming Reprocessing for Bone Tissue Engineering

doi:10.1007/s40242-017-6341-5

Chemical Research in Chinese Universities ›› 2017, Vol. 33 ›› Issue (3): 499-506.doi: 10.1007/s40242-017-6341-5

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Poly (L-lactide)-grafted Bioglass/Poly (lactide-co-glycolide) Scaffolds with Supercritical CO₂ Foaming Reprocessing for Bone Tissue Engineering

DONG Shujun¹, WANG Lin¹, LI Qiushi¹, CHEN Xuesi³, LIU Shujie¹, ZHOU Yanmin²

1. VIP Department of Stomatological Hospital of Jilin University, Changchun 130021, P. R. China;
2. Implatnt Center, Stomatological Hospital of Jilin University, Changchun 130021, P. R. China;
3. Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China

Received:2016-08-11 Revised:2017-01-25 Online:2017-06-01 Published:2017-05-26
Contact: ZHOU Yanmin,E-mail:zhouym@jlu.edu.cn E-mail:zhouym@jlu.edu.cn
Supported by:
Supported by the Key Scientific and Technological Projects of Jilin Province, China(No.20170204041GX), the National Natural Science Foundation of China(Nos.81400487, 51673190, 51673187), the State Scholarship Fund of China(No. 201506175119) and the Research Fund of Jilin University, China(Nos.3D516B703431, 3R2161193431).

Abstract

Abstract:

The bioglass particles/poly(lactide-co-glycolide)(BG/PLGA) scaffold has been extensively explored for biomedical applications due to its excellent advantages of mechanical property and controllable degradation rate. In our previous studies, the BG nanoparticle surface-grafted with poly(L-lactide)(PLLA) could substantially improve the phase compatibility between the polymer matrix and the inorganic phase and the biocompatibility of the scaffolds. However, using the traditional preparation methods to prepare the composite scaffold can barely achieve a high porosity and porous connectivity. In this work, the PLLA-grafted bioglass/PLGA(g-BG/PLGA) scaffolds were prepared by supercritical carbon dioxide foaming(Sc-CO₂) with before or after particulate leaching(PL) method(Sc-CO₂-PL or PL-Sc-CO₂ method, PL/Sc-CO₂ methods) and their applications in bone replacement and tissue engineering were investigated. The porosities of the g-BG/PLGA scaffolds prepared by the PL/Sc-CO₂ methods were higher than 90%, and their mechanical properties had similar values with human cancellous bone. The proliferations of osteoblasts on the scaffolds were dependent on different preparation methods. The PL/Sc-CO₂ methods significantly increased the proliferations of the cells. Computed tomography(CT) three-dimensional(3D) reconstruction tomographies of the implantation study for repairing calvarium defects of rabbits demonstrated that the calvarium defects were almost completely filled by the osteotylus in PL/Sc-CO₂ method group at 12 week post-surgery, while there was little callus formation in PL method group and untreated control group. These results indicate that the g-BG/PLGA scaffolds prepared by the PL/Sc-CO₂ methods exhibit rapid mineralization and osteoconductivity and are the optimal composites for bone repair.

Key words: Grafted bioglass, Compisite scaffold, Supercritical carbon dioxide foaming, Bone formation

DONG Shujun, WANG Lin, LI Qiushi, CHEN Xuesi, LIU Shujie, ZHOU Yanmin. Poly (L-lactide)-grafted Bioglass/Poly (lactide-co-glycolide) Scaffolds with Supercritical CO₂ Foaming Reprocessing for Bone Tissue Engineering[J]. Chemical Research in Chinese Universities, 2017, 33(3): 499-506.

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Poly (L-lactide)-grafted Bioglass/Poly (lactide-co-glycolide) Scaffolds with Supercritical CO₂ Foaming Reprocessing for Bone Tissue Engineering

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