CRCU

Chemical Research in Chinese Universities ›› 2016, Vol. 32 ›› Issue (6): 943-946.doi: 10.1007/s40242-016-6285-0

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Studies on Triterpenoid Glycosides from Rhizomes of Panacis majoris and Their Antiplatelet Aggregation Activity

LI Min, JIN Yongri, WANG Xiaozhong, WU Qian, LIU Ying, LI Peng, LI Xuwen   

  1. College of Chemistry, Jilin University, Changchun 130021, P. R. China
  • Received:2016-07-05 Revised:2016-09-22 Online:2016-12-01 Published:2016-10-17
  • Contact: LI Xuwen, E-mail:xwli@jlu.edu.cn E-mail:xwli@jlu.edu.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.81173602).

Abstract:

A new triterpenoid glycoside(1) and seven known triterpenoid glycosides, pseudoginsenoside RT2(2), yesanchinoside R2(3), vinaginsenoside R13(4), vinaginsenoside R8(5), notoginsenoside E(6), 6'''-O-acetylginsenoside Re(7), 6"-O-acetylginsenoside Rb1(8), were isolated from the rhizomes of Panacis majoris. The new triterpenoid glycoside was elucidated as 3-O-[β-D-glucopyranosyl-(1→2)-β-D-(6'-O-ethyl)-glucuronopyranosyl]-oleanolic acid-28-O-β-D-glucopyranoside by extensive spectroscopic and phytochemical methods. Compounds 2-8 were obtained from the plant for the first time. Compounds 3 and 4 displayed good activities against adenosine diphosphate (ADP)-induced platelet aggregation, and compounds 1, 5, 6 and 8 showed moderate activities. Compound 6 exhibited moderate antiplatelet aggregation activity induced by arachidonic acid(AA).

Key words: Panacis majoris, Rhizome, Triterpenoid glycoside, Antiplatelet aggregation