Design, Synthesis and Fungicidal Activity of Novel Strobilurin-1, 2, 4-Triazole Derivatives Containing Furan or Thiophene Rings

doi:10.1007/s40242-016-6253-9

Chemical Research in Chinese Universities ›› 2016, Vol. 32 ›› Issue (6): 952-958.doi: 10.1007/s40242-016-6253-9

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Design, Synthesis and Fungicidal Activity of Novel Strobilurin-1, 2, 4-Triazole Derivatives Containing Furan or Thiophene Rings

LIU Yang, LIU Ming, ZHANG Dongkai, HUA Xuewen, WANG Baolei, ZHOU Sha, LI Zhengming

State Key Laboratory of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Nankai University, Tianjin 300071, P. R. China

Received:2016-06-17 Revised:2016-08-12 Online:2016-12-01 Published:2016-09-05
Contact: LI Zhengming, E-mail:nkzml@vip.163.com E-mail:nkzml@vip.163.com
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21272129, 21372133).

Abstract

Abstract:

A series of strobilurin-1,2,4-triazole derivatives containing a furan or thiophen ring was designed and synthesized. The structures of the compounds were characterized by ¹H NMR, ¹³C NMR and HRMS spectra. The bi-oassays indicated that the fungicidal activities of compounds 10b(EC₅₀=14.82 mg/L) and 10c(EC₅₀=18.72 mg/L) against Cercospora arachidicola Hori in vitro were much higher than that of Azoxystrobin as control(EC₅₀=40.54 mg/L) and the fungicidal activities of compounds 10u(EC₅₀=8.66 mg/L) and 10n(EC₅₀=9.89 mg/L) against Rhizotonia cerealis in vitro were higher than that of the same control(EC₅₀=10.86 mg/L). Compounds 10b, 10c, 10n and 10k could be considered as the leading compounds for further investigation.

Key words: Strobilurin, Fungicidal activity, 1,2,4-Triazole, Azoxystrobin

LIU Yang, LIU Ming, ZHANG Dongkai, HUA Xuewen, WANG Baolei, ZHOU Sha, LI Zhengming. Design, Synthesis and Fungicidal Activity of Novel Strobilurin-1, 2, 4-Triazole Derivatives Containing Furan or Thiophene Rings[J]. Chemical Research in Chinese Universities, 2016, 32(6): 952-958.

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Design, Synthesis and Fungicidal Activity of Novel Strobilurin-1, 2, 4-Triazole Derivatives Containing Furan or Thiophene Rings

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