Temperature-controlled Cascade Reaction of Phloroglucinoltribenzyl Ether Promoted by Trifluoroacetic Anhydride and Trifluoroacetic Acid

doi:10.1007/s40242-016-5508-9

Chemical Research in Chinese Universities ›› 2016, Vol. 32 ›› Issue (3): 380-384.doi: 10.1007/s40242-016-5508-9

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Temperature-controlled Cascade Reaction of Phloroglucinoltribenzyl Ether Promoted by Trifluoroacetic Anhydride and Trifluoroacetic Acid

LI Bonan¹, DU Lijun², LI Jianqi¹

1. Novel Technology Center of Pharmaceutical Chemistry, Shanghai Institute of Pharmaceutical Industry, Shanghai 201203, P. R. China;
2. School of Life Science, Tsinghua University, Beijing 100084, P. R. China

Received:2015-12-28 Revised:2016-02-16 Online:2016-06-01 Published:2016-04-05
Contact: LI Jianqi E-mail:lijianqb@126.com
Supported by:
Supported by the National Natural Science Foundation of China(No.51209024).

Abstract

Abstract:

We report the first trifluoroacetic anhydride-and trifluoroacetic acid-promoted cascade reaction with phloroglucinoltribenzyl ether and carboxylic acid as starting materials. By simply varying the temperature of systems containing the same starting materials, different products were produced in high yields. A three-step consecutive reaction process was also proposed.

Key words: Cascade reaction, Phloroglucinol, Trifluoroacetic anhydride(TFAA), Trifluoroacetic acid(TFA)

LI Bonan, DU Lijun, LI Jianqi. Temperature-controlled Cascade Reaction of Phloroglucinoltribenzyl Ether Promoted by Trifluoroacetic Anhydride and Trifluoroacetic Acid[J]. Chemical Research in Chinese Universities, 2016, 32(3): 380-384.

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Temperature-controlled Cascade Reaction of Phloroglucinoltribenzyl Ether Promoted by Trifluoroacetic Anhydride and Trifluoroacetic Acid

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