Chemical Research in Chinese Universities ›› 2014, Vol. 30 ›› Issue (4): 587-592.doi: 10.1007/s40242-014-4069-z

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Design and Synthesis of Macrocyclic Polyoxazoles

QI Fuling1,2, GAO Lianxun1, HAN Fushe1   

  1. 1. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China;
    2. University of Chinese Academy of Sciences, Beijing 100864, P. R. China
  • Online:2014-08-01 Published:2014-05-12
  • Contact: HAN Fushe E-mail:fshan@ciac.jl.cn
  • Supported by:

    Supported by the Hundred Talent Program of Chinese Academy of Sciences and the National Natural Science Foundation of China(No.21272225).

Abstract:

Two macrocyclic polyoxazoles with different sizes and numbers of side chains were designed and synthesized from the linear-type precursors obtained by the iterative application of oxazole formation reaction via effective trimerization or dimerization respectively under highly diluted conditions in one pot.

Key words: Telomerase, Telomestatin, G-Quadruplex, Macrocyclic compound, Polyoxazole