CRCU

Chemical Research in Chinese Universities ›› 2013, Vol. 29 ›› Issue (4): 721-723.doi: 10.1007/s40242-013-3250-0

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Activities of a Novel Phenanthrene Imine to Kill Tumor Cells

WANG Xu-dong1, JIN Li-min2, SUN Zhi3, LI Dong-ni3, LIU Tie-mei3   

  1. 1. The Second Hospital of Jilin University, Changchun 130041, P. R. China;
    2. The First Hospital of Jilin University, Changchun 130021, P. R. China;
    3. China-Japan Union Hospital, Jilin University, Changchun 130033, P. R. China
  • Received:2013-06-13 Revised:2013-07-01 Online:2013-08-01 Published:2013-07-15
  • Contact: LIU Tie-mei E-mail:Liutiemei777@163.com
  • Supported by:

    Supported by the Foundation of Science and Technology Department of Jilin Province, China(No.201015186).

Abstract:

A novel phenanthrene imine was synthesized from 9,10-phenanthrenequinone, 1,4-diazabicyclo octane (Dabco), 2,6-dimethylaniline, 2,6-diisopropylaniline and TiCl4 via standard Schlenk and vacuum-line or glovebox techniques. 3-(4,5-Dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide(MTT) assay and flow cytometry(FCM) were used to detect the activities of the compound to kill tumor cells and the mechanisms of action were investigated in the study. The results show that the compound is active in killing tumor cells. Mechanistic investigations found that the compound could induce apoptosis of tumor cells.

Key words: 9,10-Phenanthrenequinone, Phenanthrene imine, Tumor killing, Apoptosis