In vitro Degradation and Biocompatibility of Ca-P Coated Magnesium Alloy

doi:10.1007/s40242-013-2314-5

Chemical Research in Chinese Universities ›› 2013, Vol. 29 ›› Issue (2): 285-289.doi: 10.1007/s40242-013-2314-5

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In vitro Degradation and Biocompatibility of Ca-P Coated Magnesium Alloy

XIAO Xing¹, ZHU Qing-san¹, SU Ying-chao², LI Guang-yu²

1. The First Hospital of Jilin University, Changchun 130021, P. R. China;
2. College of Materials Science and Engineering, Jilin University, Changchun 130022, P. R. China

Received:2012-08-22 Revised:2012-12-31 Online:2013-04-01 Published:2013-03-20
Supported by:
Supported by the National Natural Science Foundation of China(No.31070841).

Abstract

Abstract:

Calcium-phosphate compounds(Ca-P) coating was prepared on an Mg-Al alloy(AZ60). Biodegradation of Ca-P coated magnesium alloy was evaluated in simulated body fluid(SBF) by examining the changes in magnesium ion concentration and pH value, which indicated that the Ca-P coating on magnesium alloy strongly affected the corrosion of magnesium alloy. Osteoblast MC3T3-E1 cells were utilized to investigate the cellular cytocompatibility. The cytocompatibility was measured by carrying out a series of tests, such as cholecystokinin-octapeptide(CCK-8) test, alkaline phosphatase activity(ALP) test, cellular morphology of hematoxylin-eosin(HE) staining and the induction of apoptosis. It was found that the cell function showed better in the Ca-P coated Mg-alloy extract than in the uncoated magnesium alloy extract. In summary, the results indicate that the Ca-P coating can improve the corrosion resistance of magnesium alloy and elevate cellular proliferation and differentiation of osteoblast MC3T3-E1 cells.

Key words: Ca-P coating, Magnesium alloy, In vitro

XIAO Xing, ZHU Qing-san, SU Ying-chao, LI Guang-yu. In vitro Degradation and Biocompatibility of Ca-P Coated Magnesium Alloy[J]. Chemical Research in Chinese Universities, 2013, 29(2): 285-289.

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In vitro Degradation and Biocompatibility of Ca-P Coated Magnesium Alloy

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