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Chemical Research in Chinese Universities ›› 2013, Vol. 29 ›› Issue (1): 99-102.doi: 10.1007/s40242-012-2218-9

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Anti-diabetic Effects of Polysaccharides from Ethanol-insoluble Residue of Schisandra chinensis(Turcz.) Baill on Alloxan-induced Diabetic Mice

ZHAO Ting1, MAO Guang-hua1, ZHANG Min2, LI Fang1, ZOU Ye1, ZHOU Ye3, ZHENG Wei3, ZHENG Da-heng1, YANG Liu-qing2, WU Xiang-yang4   

  1. 1. College of Food and Biological Engineering, Jiangsu University, Zhenjiang 212013, P. R. China;
    2. College of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China;
    3. College of Pharmacy, Jiangsu University, Zhenjiang 212013, P. R. China;
    4. College of Environment, Jiangsu University, Zhenjiang 212013, P. R. China
  • Received:2012-06-04 Revised:2012-08-30 Online:2013-02-01 Published:2013-01-23
  • Supported by:

    Supported by the Graduate Innovative Projects in Jiangsu Province of China(No.CXZZ11-0589) and the Industry-university-research Cooperation Project of Zhenjiang City of China(No. ZJCZCXY200814).

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Abstract:

The ethanol-insoluble residue of Schisandra generated during lignans industrial production is usually treated as solid waste. However, there is active polysaccharide which could be used in it. In this work, the water-soluble polysaccharides from the ethanol-insoluble residue of Schisandra(ESCP) were obtained and their anti-diabetic effect was evaluated. The results indicate that ESCP could significantly reduce the blood glucose level in alloxan-induced diabetic mice. Moreover, the ESCP could significantly improve the lipid metabolism and increase the content of liver glycogen in alloxan-induced diabetic mice. The results indicate that ESCP could be developed into a potential natural hypoglycemic agent.

Key words: Schisandra chinensis(Turcz.) Baill, Ethanol-insoluble residue, Polysaccharide, Diabetes mellitus, Hypoglycemic activity