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高等学校化学研究 ›› 2022, Vol. 38 ›› Issue (4): 866-878.doi: 10.1007/s40242-022-2084-z

• Reviews • 上一篇    下一篇

Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors

TANG Tianwei1, LIU Yinghuan1, JIANG Ying1,2   

  1. 1. College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China;
    2. Beijing National Laboratory for Molecular Sciences, Beijing 100190, P. R. China
  • 收稿日期:2022-03-10 修回日期:2022-04-10 出版日期:2022-08-01 发布日期:2022-07-01
  • 通讯作者: JIANG Ying E-mail:yingjiang@bnu.edu.cn
  • 基金资助:
    This work was supported by the National Natural Science Foundation of China(No.22104006), the Beijing Nova Program of Science and Technology, China(No.Z191100001119108) and the Fund of Beijing National Laboratory for Molecular Sciences, China(No.BNLMS202009).

Recent Progress on Highly Selective and Sensitive Electrochemical Aptamer-based Sensors

TANG Tianwei1, LIU Yinghuan1, JIANG Ying1,2   

  1. 1. College of Chemistry, Beijing Normal University, Beijing 100875, P. R. China;
    2. Beijing National Laboratory for Molecular Sciences, Beijing 100190, P. R. China
  • Received:2022-03-10 Revised:2022-04-10 Online:2022-08-01 Published:2022-07-01
  • Contact: JIANG Ying E-mail:yingjiang@bnu.edu.cn
  • Supported by:
    This work was supported by the National Natural Science Foundation of China(No.22104006), the Beijing Nova Program of Science and Technology, China(No.Z191100001119108) and the Fund of Beijing National Laboratory for Molecular Sciences, China(No.BNLMS202009).

摘要: Highly selective, sensitive, and stable biosensors are essential for the molecular level understanding of many physiological activities and diseases. Electrochemical aptamer-based (E-AB) sensor is an appealing platform for measurement in biological system, attributing to the combined advantages of high selectivity of the aptamer and high sensitivity of electrochemical analysis. This review summarizes the latest development of E-AB sensors, focuses on the modification strategies used in the fabrication of sensors and the sensing strategies for analytes of different sizes in biological system, and then looks forward to the challenges and prospects of the future development of electrochemical aptamer-based sensors.

关键词: Electrochemical biosensor, Aptamer, Biomolecular recognition, Biological system

Abstract: Highly selective, sensitive, and stable biosensors are essential for the molecular level understanding of many physiological activities and diseases. Electrochemical aptamer-based (E-AB) sensor is an appealing platform for measurement in biological system, attributing to the combined advantages of high selectivity of the aptamer and high sensitivity of electrochemical analysis. This review summarizes the latest development of E-AB sensors, focuses on the modification strategies used in the fabrication of sensors and the sensing strategies for analytes of different sizes in biological system, and then looks forward to the challenges and prospects of the future development of electrochemical aptamer-based sensors.

Key words: Electrochemical biosensor, Aptamer, Biomolecular recognition, Biological system