Programmable Oligonucleotide-Peptide Complexes:Synthesis and Applications

doi:10.1007/s40242-021-1265-5

高等学校化学研究 ›› 2022, Vol. 38 ›› Issue (4): 856-865.doi: 10.1007/s40242-021-1265-5

Programmable Oligonucleotide-Peptide Complexes:Synthesis and Applications

XU Min¹, ZHOU Baomei¹, DING Yan^1,2, DU Shanshan¹, SU Mengke¹, LIU Honglin¹

1. China Light Industry Key Laboratory of Meat Microbial Control and Utilization, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China;
2. First Affiliated Hospital of Anhui Medical University, Hefei 230000, P. R. China

收稿日期:2021-07-13 修回日期:2021-08-15 出版日期:2022-08-01 发布日期:2022-07-01
通讯作者: SU Mengke;LIU Honglin E-mail:sumengke555@163.com;liuhonglin@mail.ustc.edu.cn
基金资助:
This work was supported by the National Key Research and Development Program of China(No.2019YFC1605900), the National Natural Science Foundation of China(Nos.21922403, 21874034), the Key Research and Development Project of Anhui Province, China(No.202104a07020013), the Fundamental Research Funds for the Central Universities, China(Nos.PA2020GDJQ0030, JZ2021HGTA0171, JZ2021HGQA0243), and the Anhui Provincial Natural Science Foundation, China(No.2108085QB84).

Programmable Oligonucleotide-Peptide Complexes:Synthesis and Applications

XU Min¹, ZHOU Baomei¹, DING Yan^1,2, DU Shanshan¹, SU Mengke¹, LIU Honglin¹

1. China Light Industry Key Laboratory of Meat Microbial Control and Utilization, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, P. R. China;
2. First Affiliated Hospital of Anhui Medical University, Hefei 230000, P. R. China

Received:2021-07-13 Revised:2021-08-15 Online:2022-08-01 Published:2022-07-01
Contact: SU Mengke;LIU Honglin E-mail:sumengke555@163.com;liuhonglin@mail.ustc.edu.cn
Supported by:
This work was supported by the National Key Research and Development Program of China(No.2019YFC1605900), the National Natural Science Foundation of China(Nos.21922403, 21874034), the Key Research and Development Project of Anhui Province, China(No.202104a07020013), the Fundamental Research Funds for the Central Universities, China(Nos.PA2020GDJQ0030, JZ2021HGTA0171, JZ2021HGQA0243), and the Anhui Provincial Natural Science Foundation, China(No.2108085QB84).

摘要/Abstract

摘要： Nucleic acids form biological blueprint and polypeptides assist life activities, both of which are indispensable to organisms. Recently, oligonucleotide-peptide complexes (OPCs) have shown great potential in biomedicine, material chemistry and other fields due to their considerable stability and programmability. It remains a huge challenge to stably and facilely constructing OPCs that also limits the wide applications. This tutorial review first summarizes the synthesis strategies of OPC conjugation and the corresponding characteristics in detail, then gives examples of the applications of OPCs, and finally presents a prospective overview on challenges and future perspectives of OPCs. This review aims to help researchers understand the current situation and challenges in this field, thereby furthering interests in developing novel OPC synthesis techniques.

关键词: Oligonucleotide, Peptide, Complex

Abstract: Nucleic acids form biological blueprint and polypeptides assist life activities, both of which are indispensable to organisms. Recently, oligonucleotide-peptide complexes (OPCs) have shown great potential in biomedicine, material chemistry and other fields due to their considerable stability and programmability. It remains a huge challenge to stably and facilely constructing OPCs that also limits the wide applications. This tutorial review first summarizes the synthesis strategies of OPC conjugation and the corresponding characteristics in detail, then gives examples of the applications of OPCs, and finally presents a prospective overview on challenges and future perspectives of OPCs. This review aims to help researchers understand the current situation and challenges in this field, thereby furthering interests in developing novel OPC synthesis techniques.

Key words: Oligonucleotide, Peptide, Complex

XU Min, ZHOU Baomei, DING Yan, DU Shanshan, SU Mengke, LIU Honglin. Programmable Oligonucleotide-Peptide Complexes:Synthesis and Applications[J]. 高等学校化学研究, 2022, 38(4): 856-865.

XU Min, ZHOU Baomei, DING Yan, DU Shanshan, SU Mengke, LIU Honglin. Programmable Oligonucleotide-Peptide Complexes:Synthesis and Applications[J]. Chemical Research in Chinese Universities, 2022, 38(4): 856-865.

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Programmable Oligonucleotide-Peptide Complexes:Synthesis and Applications

Programmable Oligonucleotide-Peptide Complexes:Synthesis and Applications

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