Chemical Research in Chinese Universities
Both electrospinning apparatus and its commercial products are extending their applications in a wide variety of fields. However, very limited reports can be found about how to implement an energy-saving process and in turn to reduce the production cost. In this paper, a brand-new type of coaxial spinneret with a solid core and its electrospinning methods are developed. A novel sort of medicated Eudragit/lipid hybrid nanofibers are generated for providing a colon-targeted sustained release of aspirin. A series of characterizations demonstrate that the as-prepared hybrid nanofibers have fine linear morphology with the aspirin/lipid separated from the matrix Eudragit to form many tiny islands. In vitro dissolution tests exhibit that the hybrid nanofibers are able to effectively prevent the release of aspirin in an acid condition (8.7¡À3.4% for the first two hours), whereas prolong the drug release time period in a neutral condition (99.7¡À4.2% at the seventh hour). The energy-saving mechanism is discussed in details. The prepared aspirin-loaded hybrid nanofibers can be further transferred into oral dosage form for potential application in against COVID-19 in future.
1 School of Materials Science & Engineering, University of Shanghai for Science & Technology, 516 Jungong Road, Shanghai 200093, China.
2 Shanghai Engineering Technology Research Center for High-Performance Medical Device Materials, 516 Jungong Road, Shanghai 200093, China
