One-step Synthesis of 5-Ethyl-2-methylpyridine from NH4HCO3 and C2H5OH Under Hydrothermal Condition

doi:10.1007/s40242-015-4297-x

Chemical Research in Chinese Universities ›› 2015, Vol. 31 ›› Issue (2): 249-252.doi: 10.1007/s40242-015-4297-x

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One-step Synthesis of 5-Ethyl-2-methylpyridine from NH₄HCO₃ and C₂H₅OH Under Hydrothermal Condition

TIAN Zhenzhen¹, ZHANG Dong², GUO Biao¹, TIAN Ge¹, LIU Xinxin¹, YUE Huijuan¹, FENG Shouhua¹

1. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, P. R. China;
2. Key Laboratory of Physics and Technology for Advance Batteries, Ministry of Education, College of Physics, Jilin University, Changchun 130012, P. R. China

Received:2014-08-04 Revised:2014-12-01 Online:2015-04-01 Published:2014-12-29
Contact: YUE Huijuan E-mail:huijuan@jlu.edu.cn
Supported by:
Supported by the Natural Science Foundation of Jilin Province, China(No.201215028), the S&T Development Program of Jilin Province, China(Nos.20130522128JH, 20140520078JH, 20150204030GX) and the National Natural Science Foundation of China(Nos.21201073, 21401070).

Abstract

Abstract:

A simple one-pot approach to synthesizing 5-ethyl-2-methylpyridine(EMP) was established using NH₄HCO₃ and C₂H₅OH as starting materials and commercial Cu₂O as catalyst and oxidant under hydrothermal condition. Different reaction conditions were researched and the optimal ones were achieved by studying the parameters, that could affect the yield of product and by considering the energy and resource saving. The present study provided an eco-friendly way to obtaining EMP with lower volatility using fewer toxic starting materials.

Key words: 5-Ethyl-2-methylpyridine, Hydrothermal condition, NH₄HCO₃, C₂H₅OH, Cu₂O

TIAN Zhenzhen, ZHANG Dong, GUO Biao, TIAN Ge, LIU Xinxin, YUE Huijuan, FENG Shouhua. One-step Synthesis of 5-Ethyl-2-methylpyridine from NH₄HCO₃ and C₂H₅OH Under Hydrothermal Condition[J]. Chemical Research in Chinese Universities, 2015, 31(2): 249-252.

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One-step Synthesis of 5-Ethyl-2-methylpyridine from NH₄HCO₃ and C₂H₅OH Under Hydrothermal Condition

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