CRCU

Chemical Research in Chinese Universities ›› 2006, Vol. 22 ›› Issue (2): 217-220.

• Articles • Previous Articles     Next Articles

Isolation and Characterization of Proteins Interacting with Activin Type H Receptors

LIU Biao1, BAO Yong-li2, WEI Zhuang1, WU Yin2, MENG Xiang-ying2, LI Yu-xin2, YIN Wei-tian1   

  1. 1. Department of Hand Surgery, China-Japan Union Hospital, Jilin University, Changchun 130031, P.R.China;

    2. Institute of Genetics and Cytology, Northeast Normal University, Changchun 130024, P.R.China
  • Received:2005-12-20 Online:2006-04-24 Published:2011-08-06
  • Supported by:

    Supported by the Distinguished Young Scholars Fund of Jilin Province(No.20050114).

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Abstract: Regulation of the number of activin receptors that are present in the cell membrane plays a key role in the modulation of cellular responses to activin.In order to find the regulators, a novel protein ARIPzip, interacting with activin type Ⅱ receptors, was searched and identified by using yeast two-hybrid screening.ARIPzip is a splicing variant of ARIP2.This has been discussed previously.ARIPzip can specifically interact with ActR Ⅱ A, and is widely distributed in mouse tissues.Overexpression of ARIPzip can cause the activin-induced transcriptional activities to increase in a dose-dependent manner while the overexpression of ARIP2 can decrease these activities.These data suggest that the C-terminal regions of ARIP2 and ARIPzip are involved in the regulation of activin signaling.

Key words: Activin, Activin receptor Ⅱ A (ActR Ⅱ A), Activin receptor interaction protein (ARIP)