CRCU

Chemical Research in Chinese Universities ›› 2006, Vol. 22 ›› Issue (1): 6-10.

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Synthesis and Anti-inflammatory Action of(η-C5H5)2Ti(Sal)2 and (η-C5H5)2Ti(Clo)2

LI Xiu-juan, ZENG Zheng-zhi   

  1. College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China
  • Received:2005-03-07 Online:2006-02-24 Published:2011-08-06
  • Supported by:

    Supported by the National Natural Science Foundation of China(No.20171019).

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Abstract: Two new complexes (Cp)2Ti(Sal)2 and(Cp)2Ti(Clo)2(Cp=Cyclopentadienyl η5-C5H5), have been synthesized in anhydrous THF by the reaction of Hsal(o-hydroxybenzoic acid, salicylate acid) or Hclo[N-(m-chloro-phe-nyl) anthranili acid, acidum clofenamicum] with (Cp)2TiCl2 and characterized by means of elemental analyses, IR, 1H NMR, 13C NMR, UV and molar conductivity. In complex (Cp)2Ti(Sal)2 or (Cp)2Ti(Clo)2, the oxygen atom of the carboxyl group coordinates to Ti(IV) in a monodentate manner. The inhibitory action of the complexes on mouse ear tumefaction caused by croton oil and rat foot granulation growth caused by cotton balls is higher than that of the corresponding ligands Hsal, Hclo and [(Cp)2TiCl2], whereas their toxicity is lower than those of the free ligands.

Key words: Salicylate acid, N-(m-Chlorophenyl) anthranilic acid, Cyclopentadienyltitanium complexes, Anti-inflammatory