Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices

doi:10.1007/s40242-020-9073-x

高等学校化学研究 ›› 2020, Vol. 36 ›› Issue (2): 185-193.doi: 10.1007/s40242-020-9073-x

Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices

DENG Mengying^1,2,3, LI Min³, MAO Xiuhai³, LI Fan³, ZUO Xiaolei³

1. Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Synchrotron Radiation Facility(SSRF), Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China;
2. University of Chinese Academy of Science, Beijing 100049, P. R. China;
3. Institute of Molecular Medicine, Renji Hospital, School of Medicine and School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200127, P. R. China

收稿日期:2019-11-29 修回日期:2019-12-18 出版日期:2020-04-01 发布日期:2020-03-18
通讯作者: ZUO Xiaolei E-mail:zuoxiaolei@sjtu.edu.cn
基金资助:
Supported by the National Natural Science Foundation of China(Nos.21904086, 21804088, 21804089 and 21804091).

Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices

DENG Mengying^1,2,3, LI Min³, MAO Xiuhai³, LI Fan³, ZUO Xiaolei³

1. Division of Physical Biology, CAS Key Laboratory of Interfacial Physics and Technology, Shanghai Synchrotron Radiation Facility(SSRF), Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, P. R. China;
2. University of Chinese Academy of Science, Beijing 100049, P. R. China;
3. Institute of Molecular Medicine, Renji Hospital, School of Medicine and School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200127, P. R. China

Received:2019-11-29 Revised:2019-12-18 Online:2020-04-01 Published:2020-03-18
Contact: ZUO Xiaolei E-mail:zuoxiaolei@sjtu.edu.cn
Supported by:
Supported by the National Natural Science Foundation of China(Nos.21904086, 21804088, 21804089 and 21804091).

摘要/Abstract

摘要： Nucleic acid probes in living organisms play an essential role in therapeutics and diagnosis. Through the imaging and sensing of nucleic acid probes in complex biological matrices, a variety of diseases-related biological process, pathogenic process, or pharmacological responses to a therapeutic intervention have been discovered. How-ever, a critical challenge of nucleic acid probes applied in complex matrices lies in enhancing the stability of nucleic acid probes, especially when it suffers from nuclease degradation and protein adsorption. In order to enhance the application of nucleic acid nanoprobes in complex matrices, great efforts have been devoted to improving the stability of probes operated in complex media, including construction of nucleic acid nanoprobes with nuclease resistance and protein adsorption resistance, sample pretreatment, anti-biofouling and signal correction. In this review, we aim to summarize recent advances in the stability of nucleic acid nanoprobes in complex matrices, including the methods of enhancing the stability of probes or signals, and the application of nucleic acid nanoprobes for disease diagnosis.

关键词: Nuclease-resistance, Complex matrix, Nucleic acid probe, Stability

Abstract: Nucleic acid probes in living organisms play an essential role in therapeutics and diagnosis. Through the imaging and sensing of nucleic acid probes in complex biological matrices, a variety of diseases-related biological process, pathogenic process, or pharmacological responses to a therapeutic intervention have been discovered. How-ever, a critical challenge of nucleic acid probes applied in complex matrices lies in enhancing the stability of nucleic acid probes, especially when it suffers from nuclease degradation and protein adsorption. In order to enhance the application of nucleic acid nanoprobes in complex matrices, great efforts have been devoted to improving the stability of probes operated in complex media, including construction of nucleic acid nanoprobes with nuclease resistance and protein adsorption resistance, sample pretreatment, anti-biofouling and signal correction. In this review, we aim to summarize recent advances in the stability of nucleic acid nanoprobes in complex matrices, including the methods of enhancing the stability of probes or signals, and the application of nucleic acid nanoprobes for disease diagnosis.

Key words: Nuclease-resistance, Complex matrix, Nucleic acid probe, Stability

DENG Mengying, LI Min, MAO Xiuhai, LI Fan, ZUO Xiaolei. Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices[J]. 高等学校化学研究, 2020, 36(2): 185-193.

DENG Mengying, LI Min, MAO Xiuhai, LI Fan, ZUO Xiaolei. Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices[J]. Chemical Research in Chinese Universities, 2020, 36(2): 185-193.

参考文献 93

[1]	Williams K. A., Veenhuizen P. T. M., de la Torre B. G., Eritja R., Dekker C., Nature, 2002, 420(6917), 761
[2]	Klug A., Rhodes D., Trends Biochem. Sci., 1987, 12, 464
[3]	Forster A. C., Symons R. H., Cell, 1987, 49(2), 211
[4]	Sen D., Gilbert W., Nature, 1988, 334(6180), 364
[5]	Parkinson G. N., Lee M. P. H., Neidle S., Nature, 2002, 417(6891), 876
[6]	Zeraati M., Langley D. B., Schofield P., Moye A. L., Rouet R., Hughes W. E., Bryan T. M., Dinger M. E., Christ D., Nat. Chem., 2018, 10(6), 631
[7]	Day H. A., Pavlou P., Waller Z. A. E., Bioorg. Med. Chem., 2014, 22(16), 4407
[8]	Song P., Ye D., Zuo X., Li J., Wang J., Liu H., Hwang M. T., Chao J., Su S., Wang L., Shi J., Wang L., Huang W., Lal R., Fan C., Nano Lett., 2017, 17(9), 5193
[9]	Lou X., Zhuang Y., Zuo X., Jia Y., Hong Y., Min X., Zhang Z., Xu X., Liu N., Xia F., Tang B. Z., Anal. Chem., 2015, 87(13), 6822
[10]	Abi A., Mohammadpour Z., Zuo X., Safavi A., Biosens. Bioelectron., 2018, 102, 479
[11]	Lin M., Yi X., Huang F., Ma X., Zuo X., Xia F., Anal. Chem., 2019, 91(3), 2021
[12]	Kaiser C. E., van Ert N. A., Agrawal P., Chawla R., Yang D., Hurley L. H., J. Am. Chem. Soc., 2017, 139(25), 8522
[13]	Brown R. V., Wang T., Chappeta V. R., Wu G., Onel B., Chawla R., Quijada H., Camp S. M., Chiang E. T., Lassiter Q. R., Lee C., Phanse S., Turnidge M. A., Zhao P., Garcia J. G. N., Gokhale V., Yang D., Hurley L. H., J. Am. Chem. Soc., 2017, 139(22), 7456
[14]	Huppert J. L., Balasubramanian S., Nucleic Acids Res., 2005, 33(9), 2908
[15]	Chambers V. S., Marsico G., Boutell J. M., Di Antonio M., Smith G. P., Balasubramanian S., Nat. Biotechnol., 2015, 33(8), 877
[16]	Rodriguez R., Miller K. M., Nat. Rev. Genet., 2014, 15(12), 783
[17]	Wolfe A. L., Singh K., Zhong Y., Drewe P., Rajasekhar V. K., Sanghvi V. R., Mavrakis K. J., Jiang M., Roderick J. E., van der Meulen J., Schatz J. H., Rodrigo C. M., Zhao C., Rondou P., de Stanchina E., Teruya-Feldstein J., Kelliher M. A., Speleman F., Porco J. A., Pelletier J., Rätsch G., Wendel H. G., Nature, 2014, 513(7516), 65
[18]	Takahashi S., Brazier J. A., Sugimoto N., Proc. Natl. Acad. Sci. USA, 2017, 114(36), 9605
[19]	Leung K., Chakraborty K., Saminathan A., Krishnan Y., Nat. Nanotechnol., 2019, 14(2), 176
[20]	Zhang F., Hong F., Yan H., Nat. Nanotechnol., 2016, 12(3), 189
[21]	Song P., Li M., Shen J., Pei H., Chao J., Su S., Aldalbahi A., Wang L., Shi J., Song S., Wang L., Fan C., Zuo X., Anal. Chem., 2016, 88(16), 8043
[22]	Mohammed A. M., Šulc P., Zenk J., Schulman R., Nat. Nanotechnol., 2016, 12(4), 312
[23]	Veetil A. T., Chakraborty K., Xiao K., Minter M. R., Sisodia S. S., Krishnan Y., Nat. Nanotechnol., 2017, 12, 1183
[24]	Praetorius F., Kick B., Behler K. L., Honemann M. N., Weuster-Botz D., Dietz H., Nature, 2017, 552(7683), 84
[25]	Han D., Pal S., Nangreave J., Deng Z., Liu Y., Yan H., Science, 2011, 332(6027), 342
[26]	Cassinelli V., Oberleitner B., Sobotta J., Nickels P., Grossi G., Kempter S., Frischmuth T., Liedl T., Manetto A., Angew. Chem., Int. Ed., 2015, 54(27), 7795
[27]	Ponnuswamy N., Bastings M. M. C., Nathwani B., Ryu J. H., Chou L. Y. T., Vinther M., Li W. A., Anastassacos F. M., Mooney D. J., Shih W. M., Nat. Commun., 2017, 8, 15654
[28]	Zaitseva M., Kaluzhny D., Shchyolkina A., Borisova O., Smirnov I., Pozmogova G., Biophys. Chem., 2010, 146(1), 1
[29]	Kiviaho J. K., Linko V., Ora A., Tiainen T., Järvihaavisto E., Mikkilä J., Tenhu H., Nonappa, Kostiainen M. A., Nanoscale, 2016, 8(22), 11674
[30]	Rosi N. L., Giljohann D. A., Thaxton C. S., Lytton-Jean A. K. R., Han M. S., Mirkin C. A., Science, 2006, 312(5776), 1027
[31]	Li H., Zhang B., Lu X., Tan X., Jia F., Xiao Y., Cheng Z., Li Y., Silva D. O., Schrekker H. S., Zhang K., Mirkin C. A., Proc. Natl. Acad. Sci. USA, 2018, 115(17), 4340
[32]	Daggumati P., Appelt S., Matharu Z., Marco M. L., Seker E., J. Am. Chem. Soc., 2016, 138(24), 7711
[33]	Arroyo-Curras N., Somerson J., Vieira P. A., Ploense K. L., Kippin T. E., Plaxco K. W., Proc. Natl. Acad. Sci. USA, 2017, 114(4), 645
[34]	Li H., Dauphin-Ducharme P., Arroyo-Currás N., Tran C. H., Vieira P. A., Li S., Shin C., Somerson J., Kippin T. E., Plaxco K. W., Angew. Chem., Int. Ed., 2017, 56(26), 7492
[35]	Li H., Arroyo-Currás N., Kang D., Ricci F., Plaxco K. W., J. Am. Chem. Soc., 2016, 138(49), 15809
[36]	Li H., Dauphin-Ducharme P., Ortega G., Plaxco K. W., J. Am. Chem. Soc., 2017, 139(32), 11207
[37]	Ferguson B. S., Hoggarth D. A., Maliniak D., Ploense K., White R. J., Woodward N., Hsieh K., Bonham A. J., Eisenstein M., Kippin T. E., Plaxco K. W., Soh H. T., Sci. Transl. Med., 2013, 5(213), 213ra165
[38]	Kawane K., Motani K., Nagata S., Cold Spring Harb Perspect Biol., 2014, 6(6), a016394
[39]	Leong K. W., Mao H. Q., Truong-Le V. L., Roy K., Walsh S. M., August J. T., J. Controlled Release, 1998, 53(1), 183
[40]	Yao W., Mei C., Nan X., Hui L., Gene, 2016, 590(1), 142
[41]	Eun H. M., In Enzymology Primer for Recombinant DNA Technology, Academic Press, San Diego, 1996
[42]	Conway J. W., McLaughlin C. K., Castor K. J., Sleiman H., Chem. Commun., 2013, 49(12), 1172
[43]	Liu M., Yin Q., Chang Y., Zhang Q., Brennan J. D., Li Y., Angew. Chem., Int. Ed., 2019, 58(24), 8013
[44]	Di Giusto D. A., King G. C., J. Biol. Chem., 2004, 279(45), 46483
[45]	Ni S., Yao H., Wang L., Lu J., Jiang F., Lu A., Zhang G., Int. J. Mol. Sci., 2017, 18(8), 1683
[46]	Turner J. J., Jones S. W., Moschos S. A., Lindsay M. A., Gait M. J., Molecular BioSystems, 2007, 3(1), 43
[47]	Deleavey G. F., Watts J. K., Damha M. J., Curr. Protoc. Nucleic Acid Chem., 2009, 39(1), 16.3.1
[48]	Dougan H., Lyster D. M., Vo C. V., Stafford A., Weitz J. I., Hobbs J. B., Nucl. Med. Biol., 2000, 27(3), 289
[49]	Liu Q., Liu G., Wang T., Fu J., Li R., Song L., Wang Z. G., Ding B., Chen F., ChemPhysChem, 2017, 18(21), 2977
[50]	Bratu D. P., Cha B. J., Mhlanga M. M., Kramer F. R., Tyagi S., Proc. Natl. Acad. Sci. USA, 2003, 100(23), 13308
[51]	Deleavey G. F., Damha M. J., Chem. Biol., 2012, 19(8), 937
[52]	Watts J. K., Corey D. R., J. Pathol., 2012, 226(2), 365
[53]	Liu Q., Ge Z., Mao X., Zhou G., Zuo X., Shen J., Shi J., Li J., Wang L., Chen X., Angew. Chem., Int. Ed., 2018, 57(24), 7131
[54]	Sze J. Y. Y., Ivanov A. P., Cass A. E. G., Edel J. B., Nat. Commun., 2017, 8(1), 1552
[55]	Valkama A. J., Leinonen H. M., Lipponen E. M., Turkki V., Malinen J., Heikura T., Ylä-Herttuala S., Lesch H. P., Gene Ther., 2017, 25(1), 39
[56]	Tay C. Y., Yuan L., Leong D. T., ACS Nano, 2015, 9(5), 5609
[57]	Zheng X., Peng R., Jiang X., Wang Y., Xu S., Ke G., Fu T., Liu Q., Huan S., Zhang X., Anal. Chem., 2017, 89(20), 10941
[58]	Jiang D., Sun Y., Li J., Li Q., Lv M., Zhu B., Tian T., Cheng D., Xia J., Zhang L., Wang L., Huang Q., Shi J., Fan C., ACS Appl. Mater. Interfaces, 2016, 8(7), 4378
[59]	Keum J. W., Bermudez H., Chem. Commun., 2009, (45), 7036
[60]	Mo Y., Turner K. T., Szlufarska I., Nature, 2009, 457(7233), 1116
[61]	Ding B., Deng Z., Yan H., Cabrini S., Zuckermann R. N., Bokor J., J. Am. Chem. Soc., 2010, 132(10), 3248
[62]	Li Z., Liu M., Wang L., Nangreave J., Yan H., Liu Y., J. Am. Chem. Soc., 2010, 132(38), 13545
[63]	Schreiber R., Kempter S., Holler S., Schüller V., Schiffels D., Simmel S. S., Nickels P. C., Liedl T., Small, 2011, 7(13), 1795
[64]	Liu J., Geng Y., Pound E., Gyawali S., Ashton J. R., Hickey J., Woolley A. T., Harb J. N., ACS Nano, 2011, 5(3), 2240
[65]	Jiang Z., Zhang S., Yang C., Kjems J., Huang Y., Besenbacher F., Dong M., Nano Res., 2015, 8(7), 2170
[66]	Mei Q., Wei X., Su F., Liu Y., Youngbull C., Johnson R., Lindsay S., Yan H., Meldrum D., Nano Lett., 2011, 11(4), 1477
[67]	Castro C. E., Kilchherr F., Kim D. N., Shiao E. L., Wauer T., Wortmann P., Bathe M., Dietz H., Nat. Methods, 2011, 8(3), 221
[68]	Lanier L. A., Bermudez H., Curr. Opin. Chem. Eng., 2015, 7, 93
[69]	Hamblin G. D., Carneiro K. M. M., Fakhoury J. F., Bujold K. E., Sleiman H. F., J. Am. Chem. Soc., 2012, 134(6), 2888
[70]	Agarwal N. P., Matthies M., Gür F. N., Osada K., Schmidt T. L., Angew. Chem., Int. Ed., 2017, 56(20), 5460
[71]	Cerda-Cristerna B. I., Flores H., Pozos-Guillén A., Pérez E., Sevrin C., Grandfils C., J. Controlled Release, 2011, 153(3), 269
[72]	Fischer D., Li Y., Ahlemeyer B., Krieglstein J., Kissel T., Biomaterials, 2003, 24(7), 1121
[73]	van Vlerken L. E., Vyas T. K., Amiji M. M., Pharm. Res., 2007, 24(8), 1405
[74]	Jiang Q., Zhao S., Liu J., Song L., Wang Z.-G., Ding B., Adv. Drug Deliv. Rev., 2019, 147, 2
[75]	Auvinen H., Zhang H., Nonappa, Kopilow A., Niemelä E. H., Nummelin S., Correia A., Santos H. A., Linko V., Kostiainen M. A., Adv. Healthcare Mater., 2017, 6(18), 1700692
[76]	Alhasan A. H., Patel P. C., Choi C. H. J., Mirkin C. A., Small, 2014, 10(1), 186
[77]	Prigodich A. E., Seferos D. S., Massich M. D., Giljohann D. A., Lane B. C., Mirkin C. A., ACS Nano, 2009, 3(8), 2147
[78]	Halo T. L., McMahon K. M., Angeloni N. L., Xu Y., Wang W., Chinen A. B., Malin D., Strekalova E., Cryns V. L., Cheng C., Mirkin C. A., Thaxton C. S., Proc. Natl. Acad. Sci. USA, 2014, 111(48), 17104
[79]	Deng M., Li M., Li F., Mao X., Li Q., Shen J., Fan C., Zuo X., ACS Mater. Lett., 2019, 1, 671
[80]	Seferos D. S., Prigodich A. E., Giljohann D. A., Patel P. C., Mirkin C. A., Nano Lett., 2009, 9(1), 308
[81]	Cutler J. I., Auyeung E., Mirkin C. A., J. Am. Chem. Soc., 2012, 134(3), 1376
[82]	Perrault S. D., Shih W. M., ACS Nano, 2014, 8(5), 5132
[83]	Barnaby S. N., Perelman G. A., Kohlstedt K. L., Chinen A. B., Schatz G. C., Mirkin C. A., Bioconjugate Chem., 2016, 27(9), 2124
[84]	Mage P. L., Ferguson B. S., Maliniak D., Ploense K. L., Kippin T. E., Soh H. T., Nat. Biomed. Eng., 2017, 1(5), 0070
[85]	Tavallaie R., McCarroll J., Le Grand M., Ariotti N., Schuhmann W., Bakker E., Tilley R. D., Hibbert D. B., Kavallaris M., Gooding J. J., Nat. Nanotechnol., 2018, 13(11), 1066
[86]	Lin M., Song P., Zhou G., Zuo X., Aldalbahi A., Lou X., Shi J., Fan C., Nat. Protoc., 2016, 11(7), 1244
[87]	Lin M., Wen Y., Li L., Pei H., Liu G., Song H., Zuo X., Fan C., Huang Q., Anal. Chem., 2014, 86(5), 2285
[88]	Wen Y., Pei H., Wan Y., Su Y., Huang Q., Song S., Fan C., Anal. Chem., 2011, 83(19), 7418
[89]	Li H., Arroyo-Currás N., Kang D., Ricci F., Plaxco K. W., J. Am. Chem. Soc., 2016, 138(49), 15809
[90]	Ge Z., Lin M., Wang P., Pei H., Yan J., Shi J., Huang Q., He D., Fan C., Zuo X., Anal. Chem., 2014, 86(4), 2124
[91]	Liu Q., Ge Z., Mao X., Zhou G., Zuo X., Shen J., Shi J., Li J., Wang L., Chen X., Fan C., Angew. Chem., Int. Ed., 2018, 57(24), 7131
[92]	Choi H. M. T., Chang J. Y., Trinh L. A., Padilla J. E., Fraser S. E., Pierce N. A., Nat. Biotechnol., 2010, 28(11), 1208
[93]	Zhang D. Y., Turberfield A. J., Yurke B., Winfree E., Science, 2007, 318(5853), 1121

Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices

Nucleic Acid Nanoprobes for Biosensor Development in Complex Matrices

可视化

摘要/Abstract

引用本文

使用本文

参考文献 93

相关文章 15

编辑推荐

Metrics

本文评价

[1]	BI Shuai, MENG Fancheng, ZHANG Zixing, WU Dongqing, ZHANG Fan. Covalent Organic Frameworks with trans-Dimensionally Vinylene-linked π-Conjugated Motifs[J]. 高等学校化学研究, 2022, 38(2): 382-395.
[2]	YE Peng, LIU Yongchao, MA Jian, WANG Yueda, FENG Xuyong, XIANG Hongfa, SUN Yi, LIANG Xin, YU Yan. Enhanced Electrochemical Performance of Na_0.67Fe_0.5Mn_0.5O₂Cathode with SnO₂ Modification[J]. 高等学校化学研究, 2021, 37(5): 1130-1136.
[3]	CAO Wenhao, WANG Caifeng, WANG Shuai, ZHANG Yang, ZHAO Ruisheng. Preparation of Photoresponsive PAN-NH₂@EPESP Fiber Films with Mechanical Stability for Regulating Wettability and Micro-environment Humidity[J]. 高等学校化学研究, 2021, 37(3): 512-521.
[4]	WANG Huanfeng, LI Jingjing, LI Fei, GUAN Dehui, WANG Xiaoxue, SU Wenhua, XU Jijing. Strategies with Functional Materials in Tackling Instability Challenges of Non-aqueous Lithium-Oxygen Batteries[J]. 高等学校化学研究, 2021, 37(2): 232-245.
[5]	LIN Qingjin, LIN Chenlu, LIU Jingying, LIU Shuang, XU Haidi, CHEN Yaoqiang, DAN Yi. Optimization of Hybrid Crystal with SAPO-5/34 on Hydrothermal Stability for deNO_x Reaction by NH₃[J]. 高等学校化学研究, 2020, 36(6): 1249-1254.
[6]	QU Huiqi, PAN Longhai, SUN Yuexin, WANG Lei, LI Yanyan, ZHANG Mingjuan, ZHANG Zhaoxiang, LIN Haifeng. Supramolecular Assemblies of Three New Metronidazole Derivatives Constructed with Various Dihydroxy-benzoic Acids via Hydrogen Bonds[J]. 高等学校化学研究, 2020, 36(6): 1196-1202.
[7]	CHEN Chaoxian, ZHAO Chenyang, LI Cuihua, LIU Jianhong, GUI Dayong. Porous NiCo₂O₄ Nanowire Arrays as Supercapacitor Electrode Materials with Extremely High Cycling Stability[J]. 高等学校化学研究, 2020, 36(4): 715-720.
[8]	PAN Tingting, YANG Kaijie, HAN Yu. Recent Progress of Atmospheric Water Harvesting Using Metal-Organic Frameworks[J]. 高等学校化学研究, 2020, 36(1): 33-40.
[9]	ZHU Xiaobo, Tobias Schulli, WANG Lianzhou. Stabilizing High-voltage Cathode Materials for Next-generation Li-ion Batteries[J]. 高等学校化学研究, 2020, 36(1): 24-32.
[10]	ZHANG Yurong, GE Xiaoguang, ZHAO Chengji, NA Hui. Comb-shaped 2-Methylimidazolium Poly(arylene ether sulfone) Anion Exchange Membranes with High Alkaline Stability[J]. 高等学校化学研究, 2019, 35(1): 150-156.
[11]	LI Kai, HE Kunhuan, LI Quanwen, XIA Bin, WANG Qinglun, ZHANG Yinghui. Crystal Structure and Photoluminescence Properties of Two Barium(Ⅱ) MOFs[J]. 高等学校化学研究, 2018, 34(5): 700-704.
[12]	WANG Mingqian, WANG Boning, LI Weiqi, ZHOU Xin, YANG Li, TIAN Weiquan. Electronic and Spectroscopic Properties of La₂@C₁₁₂ Isomers[J]. 高等学校化学研究, 2018, 34(2): 241-246.
[13]	FU Xianwei, LIU Yang, LIU Zhi, DONG Ning, ZHAO Tianyu, ZHAO Dan, LIAN Gang, WANG Qilong, CUI Deliang. Pressure-sensitive Transistor Fabricated from an OrganicSemiconductor 1,1'-Dibutyl-4,4'-bipyridinium Diiodide[J]. 高等学校化学研究, 2018, 34(1): 95-100.
[14]	XU Zhiling, LIAN Xiaowei, LI Mengjie, ZHANG Xiaodong, WANG Yi, TAO Zhu, ZHANG Qianjun. Effects of Inclusion of Chrysin in Cucurbit[8]uril on Its Stability, Solubility and Antioxidant Potential[J]. 高等学校化学研究, 2017, 33(5): 736-741.
[15]	XU Zheng, CHEN Ying, QIU Youli, GU Wenwen, LI Yu. Prediction of Stability for Polychlorinated Biphenyls in Transformer Insulation Oil Through Three-dimensional Quantitative Structure-activity Relationship Pharmacophore Model and Full Factor Experimental Design[J]. 高等学校化学研究, 2016, 32(3): 348-356.