In vivo Self-assembled Peptide Nanoprobes for Disease Diagnosis

doi:10.1007/s40242-021-1130-6

高等学校化学研究 ›› 2021, Vol. 37 ›› Issue (4): 855-869.doi: 10.1007/s40242-021-1130-6

In vivo Self-assembled Peptide Nanoprobes for Disease Diagnosis

YANG Jia^1,3, ZHENG Rui^1,4, AN Hongwei^1,2,4, WANG Hao^1,2,4

1. CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology(NCNST), Beijing 100190, P. R. China;
2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences(UCAS), Beijing 100049, P. R. China;
3. School of Future Technology, University of Chinese Academy of Sciences (UCAS), Beijing 100049, P. R. China;
4. School of Nanoscience and Technology, University of Chinese Academy of Sciences(UCAS), Beijing 100049, P. R. China

收稿日期:2021-03-17 修回日期:2021-04-18 出版日期:2021-08-01 发布日期:2021-05-20
通讯作者: AN Hongwei, WANG Hao E-mail:anhw@nanoctr.cn;wanghao@nanoctr.cn
基金资助:
This work was supported by the National Natural Science Foundation of China(Nos.52003270, 51725302, 11621505), the National Key R&D Program of China(No.2020YFA0210800), the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000), and the Key Research Program for Frontier Sciences, Chinese Academy of Sciences(No.ZDBS-LY-SLH039).

In vivo Self-assembled Peptide Nanoprobes for Disease Diagnosis

YANG Jia^1,3, ZHENG Rui^1,4, AN Hongwei^1,2,4, WANG Hao^1,2,4

1. CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology(NCNST), Beijing 100190, P. R. China;
2. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences(UCAS), Beijing 100049, P. R. China;
3. School of Future Technology, University of Chinese Academy of Sciences (UCAS), Beijing 100049, P. R. China;
4. School of Nanoscience and Technology, University of Chinese Academy of Sciences(UCAS), Beijing 100049, P. R. China

Received:2021-03-17 Revised:2021-04-18 Online:2021-08-01 Published:2021-05-20
Contact: AN Hongwei, WANG Hao E-mail:anhw@nanoctr.cn;wanghao@nanoctr.cn
Supported by:
This work was supported by the National Natural Science Foundation of China(Nos.52003270, 51725302, 11621505), the National Key R&D Program of China(No.2020YFA0210800), the Strategic Priority Research Program of Chinese Academy of Sciences(No.XDB36000000), and the Key Research Program for Frontier Sciences, Chinese Academy of Sciences(No.ZDBS-LY-SLH039).

摘要/Abstract

摘要： In vivo imaging is creating great opportunities for disease diagnosis as a research tool. Probes are usually used to observe physiological structures in vivo clearly. Recent progresses of nanoprobes are important for the generation of high resolution and high contrast images required by accurate and precision disease diagnosis. In vivo self-assembled peptide(SAP) nanoprobes are playing major roles in in vivo imaging by modularity of design, high imaging contrast, response to the location of the lesion, and long-time retention in the lesion. And the response to lesion and long-term retention in there can enhance imaging sensitivity and specificity of in vivo SAP nanoprobes. Therefore, in vivo SAP nanoprobes are simple ancillary contrast entities to optimize the imaging effect. In this review, the recent progress of in vivo SAP nanoprobes for in vivo imaging, from molecular design of peptides to biomedical and clinical applications including disease diagnosis and disease-related molecular imaging is systematically summarized. We evaluate their ability, including sensitivity and specificity to provide relevant information under preoperative and during surgery circumstances and critically their likelihood to be clinically translated. Finally, a brief outlook on remaining challenges and potential directions for future research in this area is presented.

关键词: In vivo self-assembly, Nanoprobe, Peptide, Disease diagnosis

Abstract: In vivo imaging is creating great opportunities for disease diagnosis as a research tool. Probes are usually used to observe physiological structures in vivo clearly. Recent progresses of nanoprobes are important for the generation of high resolution and high contrast images required by accurate and precision disease diagnosis. In vivo self-assembled peptide(SAP) nanoprobes are playing major roles in in vivo imaging by modularity of design, high imaging contrast, response to the location of the lesion, and long-time retention in the lesion. And the response to lesion and long-term retention in there can enhance imaging sensitivity and specificity of in vivo SAP nanoprobes. Therefore, in vivo SAP nanoprobes are simple ancillary contrast entities to optimize the imaging effect. In this review, the recent progress of in vivo SAP nanoprobes for in vivo imaging, from molecular design of peptides to biomedical and clinical applications including disease diagnosis and disease-related molecular imaging is systematically summarized. We evaluate their ability, including sensitivity and specificity to provide relevant information under preoperative and during surgery circumstances and critically their likelihood to be clinically translated. Finally, a brief outlook on remaining challenges and potential directions for future research in this area is presented.

Key words: In vivo self-assembly, Nanoprobe, Peptide, Disease diagnosis

YANG Jia, ZHENG Rui, AN Hongwei, WANG Hao. In vivo Self-assembled Peptide Nanoprobes for Disease Diagnosis[J]. 高等学校化学研究, 2021, 37(4): 855-869.

YANG Jia, ZHENG Rui, AN Hongwei, WANG Hao. In vivo Self-assembled Peptide Nanoprobes for Disease Diagnosis[J]. Chemical Research in Chinese Universities, 2021, 37(4): 855-869.

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In vivo Self-assembled Peptide Nanoprobes for Disease Diagnosis

In vivo Self-assembled Peptide Nanoprobes for Disease Diagnosis

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