Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation

doi:10.1007/s40242-022-2087-9

高等学校化学研究 ›› 2022, Vol. 38 ›› Issue (4): 847-855.doi: 10.1007/s40242-022-2087-9

Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation

CHEN Sisi, ZHANG Lei, YUAN Quan, TAN Jie

Molecular Science and Biomedicine Laboratory(MBL), Institute of Chemical Biology and Nanomedicine(ICBN), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China

收稿日期:2022-03-11 修回日期:2022-04-08 出版日期:2022-08-01 发布日期:2022-07-01
通讯作者: YUAN Quan;TAN Jie E-mail:yuanquan@whu.edu.cn;tanjie0416@hnu.edu.cn
基金资助:
This work was supported by the National Natural Science Foundation of China(Nos.22174038, 21925401, 21904037).

Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation

CHEN Sisi, ZHANG Lei, YUAN Quan, TAN Jie

Molecular Science and Biomedicine Laboratory(MBL), Institute of Chemical Biology and Nanomedicine(ICBN), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, P. R. China

Received:2022-03-11 Revised:2022-04-08 Online:2022-08-01 Published:2022-07-01
Contact: YUAN Quan;TAN Jie E-mail:yuanquan@whu.edu.cn;tanjie0416@hnu.edu.cn
Supported by:
This work was supported by the National Natural Science Foundation of China(Nos.22174038, 21925401, 21904037).

摘要/Abstract

摘要： The interaction between biomolecules with their target ligands plays a great role in regulating biological functions. Aptamers are short oligonucleotide sequences that can specifically recognize target biomolecules via structural complementarity and thus regulate related biological functions. In the past ten years, aptamers have made great progress in target biomolecule recognition, becoming a powerful tool to regulate biological functions. At present, there are many reviews on aptamers applied in biomolecular recognition, but few reviews pay attention to aptamer-based regulation of biological functions. Here, we summarize the approaches to enhancing aptamer affinity and the advancements of aptamers in regulating enzymatic activity, cellular immunity and cellular behaviors. Furthermore, this review discusses the challenges and future perspectives of aptamers in target recognition and biological functions regulation, aiming to provide some promising ideas for future regulation of biomolecular functions in a complex biological environment.

关键词: Aptamer, Molecular recognition, Biological process regulation

Abstract: The interaction between biomolecules with their target ligands plays a great role in regulating biological functions. Aptamers are short oligonucleotide sequences that can specifically recognize target biomolecules via structural complementarity and thus regulate related biological functions. In the past ten years, aptamers have made great progress in target biomolecule recognition, becoming a powerful tool to regulate biological functions. At present, there are many reviews on aptamers applied in biomolecular recognition, but few reviews pay attention to aptamer-based regulation of biological functions. Here, we summarize the approaches to enhancing aptamer affinity and the advancements of aptamers in regulating enzymatic activity, cellular immunity and cellular behaviors. Furthermore, this review discusses the challenges and future perspectives of aptamers in target recognition and biological functions regulation, aiming to provide some promising ideas for future regulation of biomolecular functions in a complex biological environment.

Key words: Aptamer, Molecular recognition, Biological process regulation

CHEN Sisi, ZHANG Lei, YUAN Quan, TAN Jie. Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation[J]. 高等学校化学研究, 2022, 38(4): 847-855.

CHEN Sisi, ZHANG Lei, YUAN Quan, TAN Jie. Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation[J]. Chemical Research in Chinese Universities, 2022, 38(4): 847-855.

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Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation

Current Advances in Aptamer-based Biomolecular Recognition and Biological Process Regulation

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