Synthesis, Crystal Structure and Biological Activities of Novel Anthranilic(Isophthalic) Acid Esters

高等学校化学研究 ›› 2012, Vol. 28 ›› Issue (1): 53-56.

Synthesis, Crystal Structure and Biological Activities of Novel Anthranilic(Isophthalic) Acid Esters

YAN Tao, YU Guan-ping, LIU Peng-fei, XIONG Li-xia, YU Shu-jing, LI Zheng-ming*

State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China

收稿日期:2011-05-09 修回日期:2011-06-10 出版日期:2012-01-25 发布日期:2011-12-27
基金资助:
Supported by the National Natural Science Foundation of China(No.20872069) and the National Basic Research Program of China(No.2010CB126106).

Synthesis, Crystal Structure and Biological Activities of Novel Anthranilic(Isophthalic) Acid Esters

YAN Tao, YU Guan-ping, LIU Peng-fei, XIONG Li-xia, YU Shu-jing, LI Zheng-ming*

State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China

Received:2011-05-09 Revised:2011-06-10 Online:2012-01-25 Published:2011-12-27
Contact: Zheng-ming LI E-mail:nkzml@vip.163.com
Supported by:
Supported by the National Natural Science Foundation of China(No.20872069) and the National Basic Research Program of China(No.2010CB126106).

摘要/Abstract

摘要： In search of environmentally benign insecticides with high activity, low toxicity and low resistance, a series of novel anthranilic(isophthalic) acid esters was designed and synthesized based on the structure of ryanodine modulating agent. All the compounds were characterized by ¹H NMR spectra, elemental analysis or high resolution mass spectrometry(HRMS). The preliminary results of biological activity assessment indicate that some of the title compounds exhibit certain but unremarkable insecticidal activity against Mythimna separata Walker at 200 mg/L and fungicidal activities against five funguses at 50 mg/L.

关键词: Anthranilic acid, Isophthalic acid, Crystal structure, Biological activity

Abstract: In search of environmentally benign insecticides with high activity, low toxicity and low resistance, a series of novel anthranilic(isophthalic) acid esters was designed and synthesized based on the structure of ryanodine modulating agent. All the compounds were characterized by ¹H NMR spectra, elemental analysis or high resolution mass spectrometry(HRMS). The preliminary results of biological activity assessment indicate that some of the title compounds exhibit certain but unremarkable insecticidal activity against Mythimna separata Walker at 200 mg/L and fungicidal activities against five funguses at 50 mg/L.

Key words: Anthranilic acid, Isophthalic acid, Crystal structure, Biological activity

YAN Tao, YU Guan-ping, LIU Peng-fei, XIONG Li-xia, YU Shu-jing, LI Zheng-ming. Synthesis, Crystal Structure and Biological Activities of Novel Anthranilic(Isophthalic) Acid Esters[J]. 高等学校化学研究, 2012, 28(1): 53-56.

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Synthesis, Crystal Structure and Biological Activities of Novel Anthranilic(Isophthalic) Acid Esters

Synthesis, Crystal Structure and Biological Activities of Novel Anthranilic(Isophthalic) Acid Esters

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