Aptamer-based Membrane Protein Analysis and Molecular Diagnostics

doi:10.1007/s40242-024-4008-6

高等学校化学研究 ›› 2024, Vol. 40 ›› Issue (2): 173-189.doi: 10.1007/s40242-024-4008-6

Aptamer-based Membrane Protein Analysis and Molecular Diagnostics

ZHAO Long¹, HU Haolan¹, MA Xiaoqian¹, LYU Yifan^1,4, YUAN Quan¹, TAN Weihong^1,2,3

1. Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, P. R. China;
2. The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, P. R. China;
3. Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China;
4. Furong Laboratory, Changsha 410082, P. R. China

收稿日期:2024-01-10 修回日期:2024-02-22 出版日期:2024-04-01 发布日期:2024-03-27
通讯作者: LYU Yifan lvyifan1990@hnu.edu.cn;YUAN Quan yuanquan@whu.edu.cn
基金资助:
This work was supported by the National Key Research and Development Project, China (No. 2020YFA0909000), the National Natural Science Foundation of China (No. 22107027), the Natural Science Foundation of Hunan Province, China (No. 2023JJ20003), and the Scientific Research Program of Furong Laboratory, China (No. 2023SK2088).

Aptamer-based Membrane Protein Analysis and Molecular Diagnostics

ZHAO Long¹, HU Haolan¹, MA Xiaoqian¹, LYU Yifan^1,4, YUAN Quan¹, TAN Weihong^1,2,3

1. Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Biology, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, P. R. China;
2. The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou 310022, P. R. China;
3. Institute of Molecular Medicine (IMM), Renji Hospital, School of Medicine, College of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China;
4. Furong Laboratory, Changsha 410082, P. R. China

Received:2024-01-10 Revised:2024-02-22 Online:2024-04-01 Published:2024-03-27
Contact: LYU Yifan lvyifan1990@hnu.edu.cn;YUAN Quan yuanquan@whu.edu.cn
Supported by:
This work was supported by the National Key Research and Development Project, China (No. 2020YFA0909000), the National Natural Science Foundation of China (No. 22107027), the Natural Science Foundation of Hunan Province, China (No. 2023JJ20003), and the Scientific Research Program of Furong Laboratory, China (No. 2023SK2088).

摘要/Abstract

摘要： Membrane proteins are vital components of the cell membrane and play crucial roles in various cellular activities. Analysis of membrane proteins is of paramount importance for studying molecular events inside cells and organisms and holds promising prospects for early disease diagnosis and treatment assessment. Benefiting from obvious merits including high affinity, high specificity and ease of modification, aptamers have been regarded as ideal molecular recognition elements in membrane protein analysis and molecular diagnostics strategies. This review summarised recent advances in membrane protein-specific aptamer screening, aptamer-based static and dynamic membrane protein analysis, and aptamer-based molecular diagnostic techniques. Prospects and challenges were also discussed.

关键词: Membrane protein, Aptamer, DNA nanotechnology, Bioanalysis, Molecular diagnostics

Abstract: Membrane proteins are vital components of the cell membrane and play crucial roles in various cellular activities. Analysis of membrane proteins is of paramount importance for studying molecular events inside cells and organisms and holds promising prospects for early disease diagnosis and treatment assessment. Benefiting from obvious merits including high affinity, high specificity and ease of modification, aptamers have been regarded as ideal molecular recognition elements in membrane protein analysis and molecular diagnostics strategies. This review summarised recent advances in membrane protein-specific aptamer screening, aptamer-based static and dynamic membrane protein analysis, and aptamer-based molecular diagnostic techniques. Prospects and challenges were also discussed.

Key words: Membrane protein, Aptamer, DNA nanotechnology, Bioanalysis, Molecular diagnostics

ZHAO Long, HU Haolan, MA Xiaoqian, LYU Yifan, YUAN Quan, TAN Weihong. Aptamer-based Membrane Protein Analysis and Molecular Diagnostics[J]. 高等学校化学研究, 2024, 40(2): 173-189.

ZHAO Long, HU Haolan, MA Xiaoqian, LYU Yifan, YUAN Quan, TAN Weihong. Aptamer-based Membrane Protein Analysis and Molecular Diagnostics[J]. Chemical Research in Chinese Universities, 2024, 40(2): 173-189.

参考文献

[1] Uhlén M., Fagerberg L., Hallström B. M., Lindskog C., Oksvold P., Mardinoglu A., Sivertsson Å., Kampf C., Sjöstedt E., Asplund A., Olsson I., Edlund K., Lundberg E., Navani S., Szigyarto C. A.-K., Odeberg J., Djureinovic D., Takanen J. O., Hober S., Alm T., Edqvist P.-H., Berling H., Tegel H., Mulder J., Rockberg J., Nilsson P., Schwenk J. M., Hamsten M., von Feilitzen K., Forsberg M., Persson L., Johansson F., Zwahlen M., von Heijne G., Nielsen J., Pontén F., Science, 2015, 347, 1260419
[2] Chatzi K. E., Sardis M. F., Karamanou S., Economou A., Biochem. J., 2013, 449, 25
[3] Hedin L. E., Illergard K., Elofsson A., J Proteome Res.,2011, 10, 3324
[4] Oradd F., Andersson M., J. Membr. Biol.,2021, 254, 51
[5] Zhang K., Gao H., Deng R., Li J., Angew. Chem. Int. Ed., 2019, 58, 4790
[6] Caricasole A., Copani A., Caruso A., Caraci F., Iacovelli L., Sortino M. A., Terstappen G. C., Nicoletti F., Trends Pharmacol. Sci., 2003, 24, 233
[7] Loibl S., Gianni L., Lancet, 2017, 389, 2415
[8] Famulok M., Hartig J. S., Mayer G., Chem. Rev.,2007, 107, 3715
[9] Levy-Nissenbaum E., Radovic-Moreno A. F., Wang A. Z., Langer R., Farokhzad O. C., Trends in Biotech., 2008, 26, 442
[10] Pestourie C., Tavitian B., Duconge F., Biochimie, 2005,87, 921
[11] Meng H.-M., Liu H., Kuai H., Peng R., Mo L., Zhang X.-B., Chem. Soc. Rev., 2016, 45, 2583
[12] Ellington A. D., Szostak J. W., Nature, 1990,346, 818
[13] Tuerk C., Gold L., Science, 1990, 249, 505
[14] Tan W., Donovan M. J., Jiang J., Chem. Rev.,2013, 113, 2842
[15] Fang X., Tan W., Acc. Chem. Res., 2009,43, 48
[16] Kong H. Y., Byun J., Biomol Ther., 2013, 21, 423
[17] Ababneh N., Alshaer W., Al-Louzi O., Mahafzah A., El-Khateeb M., Hillaireau H., Noiray M., Fattal E., Ismail S., Nucleic Acid Therapeutics, 2013, 23, 401
[18] Song Z., Mao J., Barrero R.A., Wang P., Zhang F., Wang T.,Molecules, 2020, 25, 5585
[19] Meng H.-M., Fu T., Zhang X.-B., Tan W., Natl. Sci. Rev., 2015, 2, 71
[20] Shangguan D., Li Y., Tang Z., Cao Z. C., Chen H. W., Mallikaratchy P., Sefah K., Yang C. J., Tan W., P. N. A. S.,2006, 103, 11838
[21] Lin M., Zhang J., Wan H., Yan C., Xia F., ACS Appl. Mater. Inter., 2020, 13, 9369
[22] Zhu H., Wu E., Pan Z., Zhang C., Zhang Y., Liao Q., Wang Y., Sun Y., Ye M., Wu W., Anal. Chem., 2023, 95, 3238
[23] Fang X., Tan W., Acc. Chem. Res., 2010,43, 48
[24] Gao T., Mao Z., Li W., Pei R., J. Mater. Chem. B, 2021, 9, 746
[25] Bayat P., Taghdisi S. M., Rafatpanah H., Abnous K., Ramezani M., Talanta, 2019, 194, 399
[26] Raddatz M.-S. L., Dolf A., Endl E., Knolle P., Famulok M., Mayer G., Angew. Chem. Int. Ed., 2008, 47, 5190
[27] Mayer G., Ahmed M.-S. L., Dolf A., Endl E., Knolle P. A., Famulok M., Nat. Protoc., 2010, 5, 1993
[28] Hicke B. J., Marion C., Chang Y.-F., Gould T., Lynott C. K., Parma D., Schmidt P. G., Warren S., J. Bio. Chem., 2001,276, 48644
[29] Souza A. G., Marangoni K., Fujimura P. T., Alves P. T., Silva M. J., Bastos V. A. F., Goulart L. R., Goulart V. A., Experimental Cell Research, 2016, 341, 147
[30] Lao Y.-H., Phua K. K. L., Leong K. W., ACS Nano, 2015,9, 2235
[31] Chushak Y., Stone M. O., Nucleic Acids Res., 2009,37, 87
[32] Manju N., Samiha C. M., Kumar S. P. P., Gururaj H. L., Flammini F., IEEE Access, 2022, 10, 49677
[33] Sun D., Sun M., Zhang J., Lin X., Zhang Y., Lin F., Zhang P., Yang C., Song J., TrAC Trends in Analytical Chemistry, 2022, 157, 116767
[34] Camorani S., Esposito C. L., Rienzo A., Catuogno S., Iaboni M., Condorelli G., de Franciscis V., Cerchia L., Molecular Therapy,2014, 22, 828
[35] Hu Y., Duan J., Zhan Q., Wang F., Lu X., Yang X.-D., PLoS One, 2012, 7, 31970
[36] Wang D.-L., Song Y.-L., Zhu Z., Li X.-L., Zou Y., Yang H.-T., Wang J.-J., Yao P.-S., Pan R.-J., Yang C. J., Kang D.-Z., Biochem. Bio. Res. Co., 2014, 453, 681
[37] Gao T., Ding P., Li W., Wang Z., Lin Q., Pei R., Nanoscale,2020, 12, 22574
[38] Fafińska J., Czech A., Sitz T., Ignatova Z., Hahn U., Nucleic Acid Therapeutics, 2018, 28, 326
[39] Du J., Hong J., Xu C., Cai Y., Xiang B., Zhou C., Xu X., BioMed. Res. Int., 2015, 2015, 1
[40] Bing T., Shangguan D., Wang Y., Molecular & Cellular Proteomics, 2015, 14, 2692
[41] Plummer K. A., Carothers J. M., Yoshimura M., Szostak J. W., Verdine G. L., Nucleic Acids Res., 2005, 33, 5602
[42] Jeon W., Lee S., Dh M., Ban C., Anal. Biochem., 2013,439, 11
[43] Lin C. Y., Lee C. H., Chuang Y. H., Lee J. Y., Chiu Y. Y., Wu Lee Y. H., Jong Y. J., Hwang J. K., Huang S. H., Chen L. C., Wu C. H., Tu S. H., Ho Y. S., Yang J. M., Nat. Commun., 2019, 10, 3131
[44] Huang H., Groth J., Sossey-Alaoui K., Hawthorn L., Beall S., Geradts J., Clinic. Cancer Res., 2005, 11, 4357
[45] Hosonaga M., Arima Y., Kohno N., Saya H., J. Clini. Oncol., 2014, 32, 11572
[46] Chen Y., Munteanu A. C., Huang Y. F., Phillips J., Zhu Z., Mavros M., Tan W., Chemistry, 2009, 15, 5327
[47] Shi H., He X., Wang K., Wu X., Ye X., Guo Q., Tan W., Qing Z., Yang X., Zhou B., Proc. Natl. Acad. Sci. USA,2011, 108, 3900
[48] Zhao G., Li H., Gao J., Cai M., Xu H., Shi Y., Wang H., Wang H., Anal. Chem., 2021, 93, 14113
[49] Letschert S., Göhler A., Franke C., Bertleff-Zieschang N., Memmel E., Doose S., Seibel J., Sauer M., Angew. Chem. Int. Ed., 2014, 53, 10921
[50] Chen J., Li H., Wu Q., Yan Q., Sun J., Liang F., Liu Y., Wang H., Anal. Chem., 2021, 93, 936
[51] Strauss S., Nickels P. C., Strauss M. T., Jimenez Sabinina V., Ellenberg J., Carter J. D., Gupta S., Janjic N., Jungmann R., Nature Methods, 2018, 15, 685
[52] Vaught J. D., Bock C., Carter J., Fitzwater T., Otis M., Schneider D., Rolando J., Waugh S., Wilcox S. K., Eaton B. E., J. Am. Chem. Soc., 2010, 132, 4141
[53] Rohloff J. C., Gelinas A. D., Jarvis T. C., Ochsner U. A., Schneider D. J., Gold L., Janjic N., Mol. Ther. Nucleic Acids,2014, 3, 201
[54] Jiang Y., Shi M., Liu Y., Wan S., Cui C., Zhang L., Tan W., Angew. Chem. Int. Ed. Engl., 2017,56, 11916
[55] Li L., Wang Q., Feng J., Tong L., Tang B., Anal. Chem., 2014, 86, 5101
[56] Chen Y., Munteanu A, C., Huang Y. F., Phillips J., Zhu Z., Mavros M., Tan W., Chemistry, 2009, 15, 5327
[57] Rubin C. S., Rosen O. M., Annual Rev. Biochem., 1975,44, 831
[58] Paik W. K., Paik D. C., Kim S., Trends. Biochem. Sci., 2007, 32, 146
[59] Zhao S., Xu W., Jiang W., Yu W., Lin Y., Zhang T., Yao J., Zhou L., Zeng Y., Li H., Science, 2010, 327, 1000
[60] Paleček E., Tkáč J., Bartosik M., Bertók T. S., Ostatná V., Paleček J., Chem. Rev., 2015, 115, 2045
[61] Pinho S. S., Reis C. A., Nature Rev. Cancer, 2015,15, 540
[62] Brownlee M. D. M., Annual Rev. Med., 1995, 46, 223
[63] Liddy K. A., White M. Y., Cordwell S. J., Genome Medicine, 2013, 5, 1
[64] Saxon E., Bertozzi C. R., Science, 2000, 287, 2007
[65] Jewett J.C., Bertozzi C. R., Chem. Soc. Rev., 2010, 39, 1272
[66] Robinson P. V., de Almeida-Escobedo G., de Groot A. E., McKechnie J. L., Bertozzi C. R., J. Am. Chem. Soc.,2015, 137, 10452
[67] Piston D. W., Kremers G.-J., Trends Biochem. Sci.,2007, 32, 407
[68] Yuan B., Chen Y., Sun Y., Guo Q., Huang J., Liu J., Meng X., Yang X., Wen X., Li Z., Li L., Wang K., Anal. Chem., 2018, 90, 6131
[69] Liu Z., Liang Y., Cao W., Gao W., Tang B., Anal. Chem.,2021, 93, 8915
[70] Li J., Liu S., Sun L., Li W., Zhang S.-Y., Yang S., Li J., Yang H.-H., J. Am. Chem. Soc., 2018,140, 16589
[71] Huang M., Zhu L., Kang S., Chen F., Wei X., Lin L., Chen X., Wang W., Zhu Z., Yang C., Song Y., Anal. Chem., 2021, 93, 15958
[72] Tommasone S., Allabush F., Tagger Y. K., Norman J., Kopf M., Tucker J. H. R., Mendes P. M., Chem. Soc. Rev., 2019,48, 5488
[73] Li M., Lin N., Huang Z., Du L., Altier C., Fang H., Wang B., J. Am. Chem. Soc., 2008, 130, 12636
[74] Díaz-Fernández A., Miranda-Castro R., de-los-Santos-Álvarez N., Rodríguez E. F., Lobo-Castañón M. J., Biosens. Bioelectron., 2019, 128, 83
[75] Yoshikawa A. M., Rangel A., Feagin T., Chun E. M., Wan L., Li A., Moeckl L., Wu D., Eisenstein M., Pitteri S., Soh H. T., Nat Commun.,2021, 12, 7106
[76] Cui Y., Yu M., Yao X., Xing J., Lin J., Li X., Molecular Plant, 2018, 11, 1315
[77] Kusumi A., Tsunoyama T. A., Hirosawa K. M., Kasai R. S., Fujiwara T. K., Nat. Chem. Bio., 2014, 10, 524
[78] Wolfbeis O. S., Chem. Soc. Rev., 2015,44, 4743
[79] Howarth M., Takao K., Hayashi Y., Ting A. Y., P. N.A. S., 2005, 102, 7583
[80] Chen L. Q., Xiao S. J., Hu P. P., Peng L., Ma J., Luo L. F., Li Y. F., Huang C. Z., Anal. Chem., 2012, 84, 3099
[81] Delcanale P., Porciani D., Pujals S., Jurkevich A., Chetrusca A., Tawiah K. D., Burke D. H., Albertazzi L., Angew. Chem. Int. Ed., 2020, 59, 18546
[82] Shen H., Tauzin L. J., Baiyasi R., Wang W., Moringo N., Shuang B., Landes C. F., Chem Rev., 2017, 117, 7331
[83] Zhang L., Chu M., Ji C., Wei J., Yang Y., Huang Z., Tan W., Tan J., Yuan Q., Anal. Chem., 2022, 94, 17413
[84] Albright S., Cacace M., Tivon Y., Deiters A., J. Am. Chem. Soc., 2023, 145, 16458
[85] Du Y., Lyu Y., Li S., Ding D., Chen J., Yang C., Sun Y., Qu F., Xiao Z., Jiang J., Tan W., Angew. Chem. Int. Ed.,2022, 62, 202215387
[86] Klemm J. D., Schreiber S. L., Crabtree G. R., Annu. Rev. Immunol., 1998, 16, 569
[87] Hynes N. E., Lane H. A., Nature Rev. Cancer, 2005,5, 341
[88] You M., Lyu Y., Han D., Qiu L., Liu Q., Chen T., Sam Wu C., Peng L., Zhang L., Bao G., Tan W., Nat. Nanotechnol., 2017,12, 453
[89] Fredriksson S., Gullberg M., Jarvius J., Olsson C., Pietras K., Gústafsdóttir S. M., Östman A., Landegren U., Nat. Biotechnol., 2002, 20, 473
[90] Liang H., Chen S., Li P., Wang L., Li J., Li J., Yang H. H., Tan W., J. Am. Chem. Soc., 2018, 140, 4186
[91] Wang L., Li W., Sun J., Zhang S.-Y., Yang S., Li J., Li J., Yang H. H., Anal. Chem., 2018, 90, 14433
[92] Li Y., Zhang X., Pan W., Li N., Tang B., Anal. Chem., 2020, 92, 11921
[93] Bing T., Shen L., Wang J., Wang L., Liu X., Zhang N., Xiao X., Shangguan D., Adv. Sci., 2019, 6, 1900143
[94] Dong C., Fang X., Qin X., Wang Y., Zhang J., Song C., Wang L., Anal. Chem., 2023, 95, 6810
[95] Keskin O., Gursoy A., Ma B., Nussinov R., Chem. Rev., 2008, 108, 1225
[96] Massimino M. L., Simonato M., Spolaore B., Franchin C., Arrigoni G., Marin O., Monturiol-Gross L., Fernandez J., Lomonte B., Tonello F., Sci. Rep., 2018, 8, 10619
[97] Zhu L., Xu Y., Wei X., Lin H., Huang M., Lin B., Song Y., Yang C., Angew. Chem. Int. Ed. Engl., 2021,60, 18111
[98] Mori T., Oguro A., Ohtsu T., Nakamura Y., Nucleic. Acids Res., 2004, 32, 6120
[99] Zhang H. Q., Li X. F., Le X. C., Anal. Chem., 2009,81, 7795
[100] Lee H., Kim T. H., Park D., Jang M., Chung J. J., Kim S. H., Kim S. H., Lee K. H., Jung Y., Oh S. J., Pharmaceutics,2020, 12, 689
[101] Sengupta P., Jovanovic-Talisman T., Skoko D., Renz M., Veatch S. L., Lippincott-Schwartz J.,Nature Methods, 2011, 8, 969
[102] Eraslan G., Avsec Ž., Gagneur J., Theis F.J., Nat. Rev. Genet., 2019, 20, 389
[103] Hollingsworth M. A., Swanson B. J., Nature Rev. Cancer, 2004, 4, 45
[104] Zhang Y., Chen W., Fang Y., Zhang X., Liu Y., Ju H., J. Am. Chem. Soc., 2021,143, 15233
[105] You M., Peng L., Shao N., Zhang L., Qiu L., Cui C., Tan W., J. Am. Chem. Soc.,2014, 136, 1256
[106] You M., Zhu G., Chen T., Donovan M. J., Tan W., J. Am. Chem. Soc., 2015,137, 667
[107] Feng C., Chen T., Mao D., Zhang F., Tian B., Zhu X., ACS Sens., 2020, 5, 3116
[108] El Andaloussi S., Mäger I., Breakefield X. O., Wood M. J. A., Nat. Rev. Drug Discov.,2013, 12, 347
[109] Yan H., Li Y., Cheng S., Zeng Y., Anal. Chem., 2021, 93, 4739
[110] Im H., Shao H., Park Y. I., Peterson V. M., Castro C. M., Weissleder R., Lee H., Nat. Biotechnol., 2014, 32, 490
[111] Fan Q., Yang L., Zhang X., Peng X., Wei S., Su D., Zhai Z., Hua X., Li H., Cancer Lett., 2018,414, 107
[112] Hoshino A., Kim H. S., Bojmar L., Gyan K. E., Cioffi M., Hernandez J., Zambirinis C. P., Rodrigues G., Molina H., Heissel S., Mark M. T., Steiner L., Benito-Martin A., Lucotti S., Di Giannatale A., Offer K., Nakajima M., Williams C., Nogués L., Pelissier Vatter F. A., Hashimoto A., Davies A. E., Freitas D., Kenific C. M., Ararso Y., Buehring W., Lauritzen P., Ogitani Y., Sugiura K., Takahashi N., Alečković M., Bailey K. A., Jolissant J. S., Wang H., Harris A., Schaeffer L. M., García-Santos G., Posner Z., Balachandran V. P., Khakoo Y., Raju G. P., Scherz A., Sagi I., Scherz-Shouval R., Yarden Y., Oren M., Malladi M., Petriccione M., De Braganca K. C., Donzelli M., Fischer C., Vitolano S., Wright G. P., Ganshaw L., Marrano M., Ahmed A., DeStefano J., Danzer E., Roehrl M. H. A., Lacayo N. J., Vincent T. C., Weiser M. R., Brady M. S., Meyers P. A., Wexler L. H., Ambati S. R., Chou A. J., Slotkin E. K., Modak S., Roberts S. S., Basu E. M., Diolaiti D., Krantz B. A., Cardoso F., Simpson A. L., Berger M., Rudin C. M., Simeone D. M., Jain M., Ghajar C. M., Batra S. K., Stanger B. Z., Bui J., Brown K. A., Rajasekhar V. K., Healey J. H., De Sousa M., Kramer K., Sheth S., Baisch J., Pascual V., Heaton T. E., La Quaglia M. P., Pisapia D. J., Schwartz R., Zhang H., Liu Y., Shukla A., Blavier L., DeClerck Y. A., LaBarge M., Bissell M. J., Caffrey T. C., Grandgenett P. M., Hollingsworth M. A., Bromberg J., Costa-Silva B., Peinado H., Kang Y., Garcia B. A., O’Reilly E. M., Kelsen D., Trippett T. M., Jones D. R., Matei I.R., Jarnagin W. R., Lyden D., Cell,2020, 182, 1044
[113] Li Y., Deng J., Han Z., Liu C., Tian F., Xu R., Han D., Zhang S., Sun J., J. Am. Chem. Soc., 2021, 143, 1290
[114] Yu Y., Guo Q., Jiang W., Zhang H., Cai C., Anal. Chem., 2021, 93, 11298
[115] Wu N., Zhang X.-Y., Xia J., Li X., Yang T., Wang J.-H., ACS Nano, 2021, 15, 19522
[116] Cristiano S., Leal A., Phallen J., Fiksel J., Adleff V., Bruhm D. C., Jensen S. Ø., Medina J. E., Hruban C., White J. R., Palsgrove D. N., Niknafs N., Anagnostou V., Forde P., Naidoo J., Marrone K., Brahmer J., Woodward B. D., Husain H., van Rooijen K. L., Ørntoft M.-B. W., Madsen A. H., van de Velde C. J. H., Verheij M., Cats A., Punt C.J.A., Vink G. R., van Grieken N.C.T., Koopman M., Fijneman R. J. A., Johansen J. S., Nielsen H. J., Meijer G. A., Andersen C. L., Scharpf R. B., Velculescu V. E., Nature, 2019, 570, 385
[117] Pastorino U., Silva M., Sestini S., Sabia F., Boeri M., Cantarutti A., Sverzellati N., Sozzi G., Corrao G., Marchianò A., Anna. Oncol., 2019, 30, 1162
[118] Crosby D., Bhatia S., Brindle K. M., Coussens L. M., Dive C., Emberton M., Esener S., Fitzgerald R. C., Gambhir S. S., Kuhn P., Rebbeck T. R., Balasubramanian S., Science, 2022,375, 9040
[119] Xiao S., Yao Y., Liao S., Xu B., Li X., Zhang Y., Zhang L., Chen Q., Tang H., Song Q., Dong M., Nano Lett., 2023, 23, 8115
[120] Li P., Yu X., Han W., Kong Y., Bao W., Zhang J., Zhang W., Gu Y., ACS Sens., 2019, 4, 1433
[121] Liu C., Zhao J., Tian F., Cai L., Zhang W., Feng Q., Chang J., Wan F., Yang Y., Dai B., Cong Y., Ding B., Sun J., Tan W., Nat. Biomed. Eng., 2019, 3, 183
[122] Tian F., Zhang S., Liu C., Han Z., Liu Y., Deng J., Li Y., Wu X., Cai L., Qin L., Chen Q., Yuan Y., Liu Y., Cong Y., Ding B., Jiang Z., Sun J., Nat. Commun., 2021,12, 2536
[123] Li J., Li Y., Li Q., Sun L., Tan Q., Lu Y., Zhu J., Qu F., Tan W., Angew. Chem. Int. Ed., 2024, 63, e202314262
[124] Zhou X., Jia Y., Mao C., Liu S., Cancer Lett., 2024, 580, 216481
[125] Emami N., Pakchin P. S., Ferdousi R., J. Theor. Biol., 2020, 497, 110268
[126] Thirunavukarasu D., Chen T., Liu Z., Hongdilokkul N., Romesberg F. E., J. Am. Chem. Soc., 2017, 139, 2892

Aptamer-based Membrane Protein Analysis and Molecular Diagnostics

Aptamer-based Membrane Protein Analysis and Molecular Diagnostics

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[6]	YIN Fangfei, CAO Nan, XIANG Xuelin, FENG Hao, LI Fan, LI Min, XIA Qiang, ZUO Xiaolei. DNA Framework-based Topological Aptamer for Differentiating Subtypes of Hepatocellular Carcinoma Cells[J]. 高等学校化学研究, 2021, 37(4): 919-924.
[7]	XIONG Jin'en, LI Shuang, LI Yi, CHEN Yingli, LIU Yu, GAN Junlan, JU Jiahui, XIAN Yaoling, XIONG Xiaohui. Fluorescent Aptamer-Polyethylene Glycol Functionalized Graphene Oxide Biosensor for Profenofos Detection in Food[J]. 高等学校化学研究, 2020, 36(5): 787-794.
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[9]	LI Tao, DUAN Ruilin, DUAN Zhijuan, HUANG Fujian, XIA Fan. Fluorescence Signal Amplification Strategies Based on DNA Nanotechnology for miRNA Detection[J]. 高等学校化学研究, 2020, 36(2): 194-202.
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[11]	WANG Mingyang, DUAN Jialin, DAI Lizhi, XIN Xiaodong, WANG Fangfang, LI Zheng, TIAN Ye. Characterization of 3D DNA Assemblies Using Cryogenic Electron Microscopy[J]. 高等学校化学研究, 2020, 36(2): 227-236.
[12]	DONG Yuhang, PAN Xiaorui, LI Feng, YANG Dayong. pH-Responsive Reversible DNA Self-assembly Mediated by Zwitterion[J]. 高等学校化学研究, 2020, 36(2): 285-290.
[13]	CAO Mengyao, SUN Yueyang, XIAO Mingshu, LI Li, LIU Xiaohui, JIN Hong, PEI Hao. Multivalent Aptamer-modified DNA Origami as Drug Delivery System for Targeted Cancer Therapy[J]. 高等学校化学研究, 2020, 36(2): 254-260.
[14]	LI Xue, YANG Donglei, SHEN Luyao, XU Fan, WANG Pengfei. Programmable Assembly of DNA-protein Hybrid Structures[J]. 高等学校化学研究, 2020, 36(2): 211-218.
[15]	QIN Xinyuan, SU Yuanye, TAN Jie, YUAN Quan. Artificial Nucleotide-containing Aptamers Used in Tumor Therapy[J]. 高等学校化学研究, 2020, 36(2): 164-170.